This week’s articles highlight the role of immune cell signaling heterogeneity in aging, the unlocking of poised chromatin states in migrating cells after they reach their destination, and insight into the mechanism by which PD-1–targeted immunotherapy is effective in killing cancer cells and eliminating chronic viral infections.
IMMUNOTHERAPY
CD28 is a critical target for PD-1 blockade
Immunotherapeutic PD-1–targeted therapies require CD28 to promote cancer cell killing.
IMMUNOGENOMICS
Aging and variability among immune cells
Single-cell sequencing of mouse immune cells reveals how aging destabilizes a conserved transcriptional activation program.
NEURODEVELOPMENT
The epigenetics of face-making
Different developmental programs are unlocked when the migrating cells near their final location and interact with local patterning signals.