Papers of note in Science  355 (6332)

Annalisa M. VanHook

doi:10.1126/scisignal.aan3462

This week’s articles highlight the role of immune cell signaling heterogeneity in aging, the unlocking of poised chromatin states in migrating cells after they reach their destination, and insight into the mechanism by which PD-1–targeted immunotherapy is effective in killing cancer cells and eliminating chronic viral infections.

IMMUNOTHERAPY

CD28 is a critical target for PD-1 blockade

Immunotherapeutic PD-1–targeted therapies require CD28 to promote cancer cell killing.

IMMUNOGENOMICS

Aging and variability among immune cells

Single-cell sequencing of mouse immune cells reveals how aging destabilizes a conserved transcriptional activation program.

NEURODEVELOPMENT

The epigenetics of face-making

Different developmental programs are unlocked when the migrating cells near their final location and interact with local patterning signals.

Highlighted Articles

1. A. O. Kamphorst,
2. A. Wieland,
3. T. Nasti,
4. S. Yang,
5. R. Zhang,
6. D. L. Barber,
7. B. T. Konieczny,
8. C. Z. Daugherty,
9. L. Koenig,
10. K. Yu,
11. G. L. Sica,
12. A. H. Sharpe,
13. G. J. Freeman,
14. B. R. Blazar,
15. L. A. Turka,
16. T. K. Owonikoko,
17. R. N. Pillai,
18. S. S. Ramalingam,
19. K. Araki,
20. R. Ahmed
, Rescue of exhausted CD8 T cells by PD-1–targeted therapies is CD28-dependent. Science 355, 1423–1427 (2017).
OpenUrl Abstract/FREE Full Text
1. E. Hui,
2. J. Cheung,
3. J. Zhu,
4. X. Su,
5. M. J. Taylor,
6. H. A. Wallweber,
7. D. K. Sasmal,
8. J. Huang,
9. J. M. Kim,
10. I. Mellman,
11. R. D. Vale
, T cell costimulatory receptor CD28 is a primary target for PD-1–mediated inhibition. Science 355, 1428–1433 (2017).
OpenUrl Abstract/FREE Full Text
1. D. L. Clouthier,
2. P. S. Ohashi
, Costimulation, a surprising connection for immunotherapy. Science 355, 1373–1374 (2017).
OpenUrl Abstract/FREE Full Text
1. C. P. Martinez-Jimenez,
2. N. Eling,
3. H.-C. Chen,
4. C. A. Vallejos,
5. A. A. Kolodziejczyk,
6. F. Connor,
7. L. Stojic,
8. T. F. Rayner,
9. M. J. T. Stubbington,
10. S. A. Teichmann,
11. M. de la Roche,
12. J. C. Marioni,
13. D. T. Odom
, Aging increases cell-to-cell transcriptional variability upon immune stimulation. Science 355, 1433–1436 (2017).
OpenUrl Abstract/FREE Full Text
1. M. Minoux,
2. S. Holwerda,
3. A. Vitobello,
4. T. Kitazawa,
5. H. Kohler,
6. M. B. Stadler,
7. F. M. Rijli
, Gene bivalency at Polycomb domains regulates cranial neural crest positional identity. Science 355, eaal2913 (2017).
OpenUrl Abstract/FREE Full Text

[1] A. O. Kamphorst,
A. Wieland,
T. Nasti,
S. Yang,
R. Zhang,
D. L. Barber,
B. T. Konieczny,
C. Z. Daugherty,
L. Koenig,
K. Yu,
G. L. Sica,
A. H. Sharpe,
G. J. Freeman,
B. R. Blazar,
L. A. Turka,
T. K. Owonikoko,
R. N. Pillai,
S. S. Ramalingam,
K. Araki,
R. Ahmed
, Rescue of exhausted CD8 T cells by PD-1–targeted therapies is CD28-dependent. Science 355, 1423–1427 (2017).
OpenUrl Abstract/FREE Full Text

[2] A. O. Kamphorst,

[3] A. Wieland,

[4] T. Nasti,

[5] S. Yang,

[6] R. Zhang,

[7] D. L. Barber,

[8] B. T. Konieczny,

[9] C. Z. Daugherty,

[10] L. Koenig,

[11] K. Yu,

[12] G. L. Sica,

[13] A. H. Sharpe,

[14] G. J. Freeman,

[15] B. R. Blazar,

[16] L. A. Turka,

[17] T. K. Owonikoko,

[18] R. N. Pillai,

[19] S. S. Ramalingam,

[20] K. Araki,

[21] R. Ahmed

[22] E. Hui,
J. Cheung,
J. Zhu,
X. Su,
M. J. Taylor,
H. A. Wallweber,
D. K. Sasmal,
J. Huang,
J. M. Kim,
I. Mellman,
R. D. Vale
, T cell costimulatory receptor CD28 is a primary target for PD-1–mediated inhibition. Science 355, 1428–1433 (2017).
OpenUrl Abstract/FREE Full Text

[23] E. Hui,

[24] J. Cheung,

[25] J. Zhu,

[26] X. Su,

[27] M. J. Taylor,

[28] H. A. Wallweber,

[29] D. K. Sasmal,

[30] J. Huang,

[31] J. M. Kim,

[32] I. Mellman,

[33] R. D. Vale

[34] D. L. Clouthier,
P. S. Ohashi
, Costimulation, a surprising connection for immunotherapy. Science 355, 1373–1374 (2017).
OpenUrl Abstract/FREE Full Text

[35] D. L. Clouthier,

[36] P. S. Ohashi

[37] C. P. Martinez-Jimenez,
N. Eling,
H.-C. Chen,
C. A. Vallejos,
A. A. Kolodziejczyk,
F. Connor,
L. Stojic,
T. F. Rayner,
M. J. T. Stubbington,
S. A. Teichmann,
M. de la Roche,
J. C. Marioni,
D. T. Odom
, Aging increases cell-to-cell transcriptional variability upon immune stimulation. Science 355, 1433–1436 (2017).
OpenUrl Abstract/FREE Full Text

[38] C. P. Martinez-Jimenez,

[39] N. Eling,

[40] H.-C. Chen,

[41] C. A. Vallejos,

[42] A. A. Kolodziejczyk,

[43] F. Connor,

[44] L. Stojic,

[45] T. F. Rayner,

[46] M. J. T. Stubbington,

[47] S. A. Teichmann,

[48] M. de la Roche,

[49] J. C. Marioni,

[50] D. T. Odom

[51] M. Minoux,
S. Holwerda,
A. Vitobello,
T. Kitazawa,
H. Kohler,
M. B. Stadler,
F. M. Rijli
, Gene bivalency at Polycomb domains regulates cranial neural crest positional identity. Science 355, eaal2913 (2017).
OpenUrl Abstract/FREE Full Text

[52] M. Minoux,

[53] S. Holwerda,

[54] A. Vitobello,

[55] T. Kitazawa,

[56] H. Kohler,

[57] M. B. Stadler,

[58] F. M. Rijli

Papers of note in Science 355 (6332)

Highlighted Articles

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