Papers of note in Nature 543 (7647)

John F. Foley

doi:10.1126/scisignal.aan3518

This week’s articles highlight how cancer stem cells drive metastasis, but not primary tumor growth, and how a mitochondrial protein changes lipid metabolism to inhibit the proliferation of breast cancer cells.

CANCER

Lgr5-positive cells drive metastasis

de Sousa e Melo et al. found that deletion of cancer stem cells expressing the GPCR Lrg5 from mouse intestinal tumors did not prevent tumor growth, but instead prevented metastisis to the liver (see also Greten).

Mitochondrial lipid metabolism and tumorigenesis

Keckesova et al. show that the mitochondrial protein LACTB suppresses the proliferation of breast cancer cells by altering lipid metabolism and differentiation state.

Highlighted Articles

1. F. de Sousa e Melo,
2. A. V. Kurtova,
3. J. M. Harnoss,
4. N. Kljavin,
5. J. D. Hoeck,
6. J. Hung,
7. J. E. Anderson,
8. E. E. Storm,
9. Z. Modrusan,
10. H. Koeppen,
11. G. J. P. Dijkgraaf,
12. R. Piskol,
13. F. J. de Sauvage
, A distinct role for Lgr5⁺ stem cells in primary and metastatic colon cancer. Nature 543, 676–680 (2017).
OpenUrl
1. F. R. Greten
, Tumour stem-cell surprises. Nature 543, 626–627 (2017).
OpenUrl
1. Z. Keckesova,
2. J. L. Donaher,
3. J. De Cock,
4. E. Freinkman,
5. S. Lingrell,
6. D. A. Bachovchin,
7. B. Bierie,
8. V. Tischler,
9. A. Noske,
10. M. C. Okondo,
11. F. Reinhardt,
12. P. Thiru,
13. T. R. Golub,
14. J. E. Vance,
15. R. A. Weinberg
, LACTB is a tumour suppressor that modulates lipid metabolism and cell state. Nature 543, 681–686 (2017).
OpenUrl

[1] F. de Sousa e Melo,
A. V. Kurtova,
J. M. Harnoss,
N. Kljavin,
J. D. Hoeck,
J. Hung,
J. E. Anderson,
E. E. Storm,
Z. Modrusan,
H. Koeppen,
G. J. P. Dijkgraaf,
R. Piskol,
F. J. de Sauvage
, A distinct role for Lgr5⁺ stem cells in primary and metastatic colon cancer. Nature 543, 676–680 (2017).
OpenUrl

[2] F. de Sousa e Melo,

[3] A. V. Kurtova,

[4] J. M. Harnoss,

[5] N. Kljavin,

[6] J. D. Hoeck,

[7] J. Hung,

[8] J. E. Anderson,

[9] E. E. Storm,

[10] Z. Modrusan,

[11] H. Koeppen,

[12] G. J. P. Dijkgraaf,

[13] R. Piskol,

[14] F. J. de Sauvage

[15] F. R. Greten
, Tumour stem-cell surprises. Nature 543, 626–627 (2017).
OpenUrl

[16] F. R. Greten

[17] Z. Keckesova,
J. L. Donaher,
J. De Cock,
E. Freinkman,
S. Lingrell,
D. A. Bachovchin,
B. Bierie,
V. Tischler,
A. Noske,
M. C. Okondo,
F. Reinhardt,
P. Thiru,
T. R. Golub,
J. E. Vance,
R. A. Weinberg
, LACTB is a tumour suppressor that modulates lipid metabolism and cell state. Nature 543, 681–686 (2017).
OpenUrl

[18] Z. Keckesova,

[19] J. L. Donaher,

[20] J. De Cock,

[21] E. Freinkman,

[22] S. Lingrell,

[23] D. A. Bachovchin,

[24] B. Bierie,

[25] V. Tischler,

[26] A. Noske,

[27] M. C. Okondo,

[28] F. Reinhardt,

[29] P. Thiru,

[30] T. R. Golub,

[31] J. E. Vance,

[32] R. A. Weinberg

Papers of note in Nature 543 (7647)

Highlighted Articles

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