Editors' ChoiceImmunology

Papers of note in Science Immunology 2 (9)

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Science Signaling  04 Apr 2017:
Vol. 10, Issue 473, eaan3523
DOI: 10.1126/scisignal.aan3523

This month’s articles show how an anti-inflammatory mediator is required for allergic responses, how targeting of the deacetylase Sirtuin 1 may provide a therapy against Mycobacterium tuberculosis infection, and how an inhibitory receptor limits the proliferation of regulatory T cells in autoimmune diabetes.


Type 2 immunity on PPAR

Chen et al. showed that PPAR-γ, which is thought to be anti-inflammatory, mediated allergic responses, thus complicating the use of PPAR-γ agonists in treating disease.


Mtb faces Sirtuin death

Cheng et al. showed that activation of the NAD+-dependent deacetylase Sirtuin 1 inhibited the intracellular growth of Mycobacterium tuberculosis and decreased lung pathology in mice.


Regulating the regulators

Zhang et al. showed that deletion of the inhibitory receptor LAG3 from regulatory T cells reduced the incidence of autoimmune diabetes in nonobese diabetic mice.

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