This month’s articles show how an anti-inflammatory mediator is required for allergic responses, how targeting of the deacetylase Sirtuin 1 may provide a therapy against Mycobacterium tuberculosis infection, and how an inhibitory receptor limits the proliferation of regulatory T cells in autoimmune diabetes.
ALLERGY
Type 2 immunity on PPAR
Chen et al. showed that PPAR-γ, which is thought to be anti-inflammatory, mediated allergic responses, thus complicating the use of PPAR-γ agonists in treating disease.
INFECTIOUS DISEASE
Mtb faces Sirtuin death
Cheng et al. showed that activation of the NAD+-dependent deacetylase Sirtuin 1 inhibited the intracellular growth of Mycobacterium tuberculosis and decreased lung pathology in mice.
AUTOIMMUNITY
Regulating the regulators
Zhang et al. showed that deletion of the inhibitory receptor LAG3 from regulatory T cells reduced the incidence of autoimmune diabetes in nonobese diabetic mice.
