Contents
11 April 2017
Vol 10, Issue 474
Vol 10, Issue 474
Research Articles
- The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB
Inhibiting the activity of the transcription factor MAFK may suppress the progression of triple-negative breast cancer.
- YAP-mediated mechanotransduction determines the podocyte’s response to damage
Mechanosensitive activation of YAP is an early response in damaged kidneys.
Research Resource
- Genomics and evolution of protein phosphatases
Genomic analysis provides a global catalog of phosphatases, a key component of cell signaling.
Editors' Choice
- Hippo-sized antiviral defenses
The Hippo signaling pathway modulates the strength of antiviral responses according to nutritional status or cell density.
- NLS protects DNA damage protein
A single motif targets a protein to the nucleus and directs its deubiquitylation, promoting high-fidelity DNA damage repair.
- Papers of note in Science 356 (6333)
This week’s articles identify a potential cause for the development of celiac disease and a method for targeting an AMPA receptor agonist to specific neurons.
- Papers of note in Science Translational Medicine 9 (384)
This week’s articles reveal how drugs that prime the tumor stroma can enhance chemotherapy and how disrupting select chemokine interactions might treat inflammatory disease.
- Papers of note in Nature 544 (7648)
This week’s highlighted article shows that adiponectin receptors may transduce signaling by acting as ceramidases.
About The Cover
Online Cover This week features a Research Resource that characterizes the human phosphatome and its evolution. The image shows the phosphatome tree. [Image: Anne Ashley, Pixelmap Productions; Mark J. Chen, Genentech Inc.; and Gerard Manning, Genentech Inc.]