This week’s articles reveal how drugs that prime the tumor stroma can enhance chemotherapy and how disrupting select chemokine interactions might treat inflammatory disease.
CANCER
ROCK-ing pancreatic cancer to the core
Vennin et al. used a clinically approved drug that inhibits the kinase ROCK to decrease tension in the tumor stroma and improve chemotherapeutic efficacy against pancreatic cancer.
INFLAMMATION
Hampering heterodimers interrupts inflammation
Upon mapping the chemokine interactome, von Hundelshausen et al. discovered that inhibiting the formation of selective chemokine heterodimers may be therapeutic for patients with inflammatory disease.