Papers of note in Science Translational Medicine 9 (384)

Leslie K. Ferrarelli

doi:10.1126/scisignal.aan3929

This week’s articles reveal how drugs that prime the tumor stroma can enhance chemotherapy and how disrupting select chemokine interactions might treat inflammatory disease.

CANCER

ROCK-ing pancreatic cancer to the core

Vennin et al. used a clinically approved drug that inhibits the kinase ROCK to decrease tension in the tumor stroma and improve chemotherapeutic efficacy against pancreatic cancer.

INFLAMMATION

Hampering heterodimers interrupts inflammation

Upon mapping the chemokine interactome, von Hundelshausen et al. discovered that inhibiting the formation of selective chemokine heterodimers may be therapeutic for patients with inflammatory disease.

Highlighted Articles

1. C. Vennin,
2. V. T. Chin,
3. S. C. Warren,
4. M. C. Lucas,
5. D. Herrmann,
6. A. Magenau,
7. P. Melenec,
8. S. N. Walters,
9. G. del Monte-Nieto,
10. J. R. W. Conway,
11. M. Nobis,
12. A. H. Allam,
13. R. A. McCloy,
14. N. Currey,
15. M. Pinese,
16. A. Boulghourjian,
17. A. Zaratzian,
18. A. A. S. Adam,
19. C. Heu,
20. A. M. Nagrial,
21. A. Chou,
22. A. Steinmann,
23. A. Drury,
24. D. Froio,
25. M. Giry-Laterriere,
26. N. L. E. Harris,
27. T. Phan,
28. R. Jain,
29. W. Weninger,
30. E. J. McGhee,
31. R. Whan,
32. A. L. Johns,
33. J. S. Samra,
34. L. Chantrill,
35. A. J. Gill,
36. M. Kohonen-Corish,
37. R. P. Harvey,
38. A. V. Biankin,
39. Australian Pancreatic Cancer Genome Initiative (APGI),
40. T. R. J. Evans,
41. K. I. Anderson,
42. S. T. Grey,
43. C. J. Ormandy,
44. D. Gallego-Ortega,
45. Y. Wang,
46. M. S. Samuel,
47. O. J. Sansom,
48. A. Burgess,
49. T. R. Cox,
50. J. P. Morton,
51. M. Pajic,
52. P. Timpson
, Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis. Sci. Transl. Med. 9, eaai8504 (2017).
OpenUrl Abstract/FREE Full Text
1. P. von Hundelshausen,
2. S. M. Agten,
3. V. Eckardt,
4. X. Blanchet,
5. M. M. Schmitt,
6. H. Ippel,
7. C. Neideck,
8. K. Bidzhekov,
9. J. Leberzammer,
10. K. Wichapong,
11. A. Faussner,
12. M. Drechsler,
13. J. Grommes,
14. J. P. van Geffen,
15. H. Li,
16. A. Ortega-Gomez,
17. R. T. A. Megens,
18. R. Naumann,
19. I. Dijkgraaf,
20. G. A. F. Nicolaes,
21. Y. Döring,
22. O. Soehnlein,
23. E. Lutgens,
24. J. W. M. Heemskerk,
25. R. R. Koenen,
26. K. H. Mayo,
27. T. M. Hackeng,
28. C. Weber
, Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation. Sci. Transl. Med. 9, eaah6650 (2017).
OpenUrl Abstract/FREE Full Text

This week’s articles reveal how drugs that prime the tumor stroma can enhance chemotherapy and how disrupting select chemokine interactions might treat inflammatory disease.

[1] C. Vennin,
V. T. Chin,
S. C. Warren,
M. C. Lucas,
D. Herrmann,
A. Magenau,
P. Melenec,
S. N. Walters,
G. del Monte-Nieto,
J. R. W. Conway,
M. Nobis,
A. H. Allam,
R. A. McCloy,
N. Currey,
M. Pinese,
A. Boulghourjian,
A. Zaratzian,
A. A. S. Adam,
C. Heu,
A. M. Nagrial,
A. Chou,
A. Steinmann,
A. Drury,
D. Froio,
M. Giry-Laterriere,
N. L. E. Harris,
T. Phan,
R. Jain,
W. Weninger,
E. J. McGhee,
R. Whan,
A. L. Johns,
J. S. Samra,
L. Chantrill,
A. J. Gill,
M. Kohonen-Corish,
R. P. Harvey,
A. V. Biankin,
Australian Pancreatic Cancer Genome Initiative (APGI),
T. R. J. Evans,
K. I. Anderson,
S. T. Grey,
C. J. Ormandy,
D. Gallego-Ortega,
Y. Wang,
M. S. Samuel,
O. J. Sansom,
A. Burgess,
T. R. Cox,
J. P. Morton,
M. Pajic,
P. Timpson
, Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis. Sci. Transl. Med. 9, eaai8504 (2017).
OpenUrl Abstract/FREE Full Text

[2] C. Vennin,

[3] V. T. Chin,

[4] S. C. Warren,

[5] M. C. Lucas,

[6] D. Herrmann,

[7] A. Magenau,

[8] P. Melenec,

[9] S. N. Walters,

[10] G. del Monte-Nieto,

[11] J. R. W. Conway,

[12] M. Nobis,

[13] A. H. Allam,

[14] R. A. McCloy,

[15] N. Currey,

[16] M. Pinese,

[17] A. Boulghourjian,

[18] A. Zaratzian,

[19] A. A. S. Adam,

[20] C. Heu,

[21] A. M. Nagrial,

[22] A. Chou,

[23] A. Steinmann,

[24] A. Drury,

[25] D. Froio,

[26] M. Giry-Laterriere,

[27] N. L. E. Harris,

[28] T. Phan,

[29] R. Jain,

[30] W. Weninger,

[31] E. J. McGhee,

[32] R. Whan,

[33] A. L. Johns,

[34] J. S. Samra,

[35] L. Chantrill,

[36] A. J. Gill,

[37] M. Kohonen-Corish,

[38] R. P. Harvey,

[39] A. V. Biankin,

[40] Australian Pancreatic Cancer Genome Initiative (APGI),

[41] T. R. J. Evans,

[42] K. I. Anderson,

[43] S. T. Grey,

[44] C. J. Ormandy,

[45] D. Gallego-Ortega,

[46] Y. Wang,

[47] M. S. Samuel,

[48] O. J. Sansom,

[49] A. Burgess,

[50] T. R. Cox,

[51] J. P. Morton,

[52] M. Pajic,

[53] P. Timpson

[54] P. von Hundelshausen,
S. M. Agten,
V. Eckardt,
X. Blanchet,
M. M. Schmitt,
H. Ippel,
C. Neideck,
K. Bidzhekov,
J. Leberzammer,
K. Wichapong,
A. Faussner,
M. Drechsler,
J. Grommes,
J. P. van Geffen,
H. Li,
A. Ortega-Gomez,
R. T. A. Megens,
R. Naumann,
I. Dijkgraaf,
G. A. F. Nicolaes,
Y. Döring,
O. Soehnlein,
E. Lutgens,
J. W. M. Heemskerk,
R. R. Koenen,
K. H. Mayo,
T. M. Hackeng,
C. Weber
, Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation. Sci. Transl. Med. 9, eaah6650 (2017).
OpenUrl Abstract/FREE Full Text

[55] P. von Hundelshausen,

[56] S. M. Agten,

[57] V. Eckardt,

[58] X. Blanchet,

[59] M. M. Schmitt,

[60] H. Ippel,

[61] C. Neideck,

[62] K. Bidzhekov,

[63] J. Leberzammer,

[64] K. Wichapong,

[65] A. Faussner,

[66] M. Drechsler,

[67] J. Grommes,

[68] J. P. van Geffen,

[69] H. Li,

[70] A. Ortega-Gomez,

[71] R. T. A. Megens,

[72] R. Naumann,

[73] I. Dijkgraaf,

[74] G. A. F. Nicolaes,

[75] Y. Döring,

[76] O. Soehnlein,

[77] E. Lutgens,

[78] J. W. M. Heemskerk,

[79] R. R. Koenen,

[80] K. H. Mayo,

[81] T. M. Hackeng,

[82] C. Weber

Papers of note in Science Translational Medicine 9 (384)

Highlighted Articles

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