The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation

Kate Senger; Victoria C. Pham; Eugene Varfolomeev; Jason A. Hackney; Cesar A. Corzo; Jenna Collier; Vivian W. C. Lau; Zhiyu Huang; Kajal Hamidzhadeh; Patrick Caplazi; Ivan Peng; A. Francesca Setiadi; Ross Francis; Andres Paler-Martinez; Youngsu C. Kwon; Vladimir Ramirez-Carrozzi; Yonglian Sun; Patricia W. Grigg; Merone Roose-Girma; Surinder Jeet; Kai H. Barck; Anna Pham; Naruhisa Ota; Connie Ha; Jeremy Stinson; Joseph Guillory; Lucinda Tam; Zora Modrusan; Claire Emson; Brent S. McKenzie; Michael J. Townsend; Richard A. D. Carano; Søren Warming; Domagoj Vucic; Jason DeVoss; Wyne P. Lee; Jennie R. Lill; Ali A. Zarrin

doi:10.1126/scisignal.aah4273

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Science Signaling

Vol 10, Issue 475
18 April 2017

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The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation

By Kate Senger, Victoria C. Pham, Eugene Varfolomeev, Jason A. Hackney, Cesar A. Corzo, Jenna Collier, Vivian W. C. Lau, Zhiyu Huang, Kajal Hamidzhadeh, Patrick Caplazi, Ivan Peng, A. Francesca Setiadi, Ross Francis, Andres Paler-Martinez, Youngsu C. Kwon, Vladimir Ramirez-Carrozzi, Yonglian Sun, Patricia W. Grigg, Merone Roose-Girma, Surinder Jeet, Kai H. Barck, Anna Pham, Naruhisa Ota, Connie Ha, Jeremy Stinson, Joseph Guillory, Lucinda Tam, Zora Modrusan, Claire Emson, Brent S. McKenzie, Michael J. Townsend, Richard A. D. Carano, Søren Warming, Domagoj Vucic, Jason DeVoss, Wyne P. Lee, Jennie R. Lill, Ali A. Zarrin

Science Signaling18 Apr 2017

A small-molecule inhibitor of the kinase TPL2 shows efficacy in rodent models of inflammation.

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The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation

By Kate Senger, Victoria C. Pham, Eugene Varfolomeev, Jason A. Hackney, Cesar A. Corzo, Jenna Collier, Vivian W. C. Lau, Zhiyu Huang, Kajal Hamidzhadeh, Patrick Caplazi, Ivan Peng, A. Francesca Setiadi, Ross Francis, Andres Paler-Martinez, Youngsu C. Kwon, Vladimir Ramirez-Carrozzi, Yonglian Sun, Patricia W. Grigg, Merone Roose-Girma, Surinder Jeet, Kai H. Barck, Anna Pham, Naruhisa Ota, Connie Ha, Jeremy Stinson, Joseph Guillory, Lucinda Tam, Zora Modrusan, Claire Emson, Brent S. McKenzie, Michael J. Townsend, Richard A. D. Carano, Søren Warming, Domagoj Vucic, Jason DeVoss, Wyne P. Lee, Jennie R. Lill, Ali A. Zarrin

Science Signaling18 Apr 2017

A small-molecule inhibitor of the kinase TPL2 shows efficacy in rodent models of inflammation.

Supplementary Materials
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