Paper of note in Science 356 (6334)

Annalisa M. VanHook

doi:10.1126/scisignal.aan4392

This week’s article highlights the contribution of T cell reactivity to nonviral antigens to the success of adoptive T cell transfer in treating a virus-driven cancer.

IMMUNOTHERAPY

Targeting nonviral antigens in viral-driven cancer

Stevanović et al. report that reactive T cells directed against nonviral antigens lead to regression of human papilloma virus–positive cervical cancer.

Highlighted Article

1. S. Stevanović,
2. A. Pasetto,
3. S. R. Helman,
4. J. J. Gartner,
5. T. D. Prickett,
6. B. Howie,
7. H. S. Robins,
8. P. F. Robbins,
9. C. A. Klebanoff,
10. S. A. Rosenberg,
11. C. S. Hinrichs
, Landscape of immunogenic tumor antigens in successful immunotherapy of virally induced epithelial cancer. Science 356, 200–205 (2017).
OpenUrl Abstract/FREE Full Text

View Abstract

This week’s article highlights the contribution of T cell reactivity to nonviral antigens to the success of adoptive T cell transfer in treating a virus-driven cancer.

[1] S. Stevanović,
A. Pasetto,
S. R. Helman,
J. J. Gartner,
T. D. Prickett,
B. Howie,
H. S. Robins,
P. F. Robbins,
C. A. Klebanoff,
S. A. Rosenberg,
C. S. Hinrichs
, Landscape of immunogenic tumor antigens in successful immunotherapy of virally induced epithelial cancer. Science 356, 200–205 (2017).
OpenUrl Abstract/FREE Full Text

[2] S. Stevanović,

[3] A. Pasetto,

[4] S. R. Helman,

[5] J. J. Gartner,

[6] T. D. Prickett,

[7] B. Howie,

[8] H. S. Robins,

[9] P. F. Robbins,

[10] C. A. Klebanoff,

[11] S. A. Rosenberg,

[12] C. S. Hinrichs

Paper of note in Science 356 (6334)

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