Contents
25 April 2017
Vol 10, Issue 476
Vol 10, Issue 476
Research Articles
- p53 dynamics in response to DNA damage vary across cell lines and are shaped by efficiency of DNA repair and activity of the kinase ATM
Single-cell imaging shows that the p53 response to DNA damage is dynamic and cell line–specific.
- Unphosphorylated ISGF3 drives constitutive expression of interferon-stimulated genes to protect against viral infections
A tripartite transcription factor complex mediates an interferon-independent antiviral response.
Research Resource
- Discovering relationships between nuclear receptor signaling pathways, genes, and tissues in Transcriptomine
An updated data-mining web tool enables researchers to understand how nuclear receptors affect genes or cellular processes of interest.
Editors' Choice
- Active life, active antitumor defense
An active lifestyle in mice stimulates adrenergic signaling in the nervous system that enhances the function of antitumor natural killer cells.
- Blocking a signal to host cell histones
A plant pathogen suppresses the host immune response by preventing histone acetylation.
- Papers of note in Science 356 (6335)
This week’s articles highlight a peptide that controls myoblast fusion; a metabolic adaptation that enables naked mole-rats to resist the detrimental effects of anoxia; a transcription factor that coordinates signaling in the mammary epithelial stem cell niche; and transgenerational epigenetic inheritance of the response to an environmental stimulus.
- Papers of note in Science Translational Medicine 9 (386)
This week’s articles describe a new hydrogel that promotes chronic wound healing and a way to limit intestinal tissue damage from radiation, chemo, or hematopoietic cell transplant therapies.
- Papers of note in Nature 544 (7650)
This week’s articles show that vesicle fusion proteins are involved in long-term potentiation and highlight the structural properties that contribute to functional differences between angiotensin II receptors.
About The Cover
Online Cover This week features a Research Article that uses single-cell imaging to reveal that p53 induction in response to DNA damage is dynamic and varies substantially between single cells and between cell lines, even of the same tissue type. The patterns of p53 oscillation varied with the efficiency of each cell's DNA damage response and repair pathways. [Image: agsandrew/istockphoto]