Papers of note in Science Translational Medicine 9 (386)

Leslie K. Ferrarelli

doi:10.1126/scisignal.aan4922

This week’s articles describe a new hydrogel that promotes chronic wound healing and a way to limit intestinal tissue damage from radiation, chemo, or hematopoietic cell transplant therapies.

WOUND HEALING

Capturing chemokines in chronic wounds

Lohmann et al. show that a heparin-based hydrogel sequesters proinflammatory chemokines, reduces inflammation, and promotes tissue regeneration in chronic wounds.

INTESTINAL INTEGRITY

Innate immune signaling protects the gut

Fischer et al. report that activation of the innate immune pathways mediated by RIG-I or STING protects the gut after irradiation or hematopoietic transplant therapy.

Highlighted Articles

1. N. Lohmann,
2. L. Schirmer,
3. P. Atallah,
4. E. Wandel,
5. R. A. Ferrer,
6. C. Werner,
7. J. C. Simon,
8. S. Franz,
9. U. Freudenberg
, Glycosaminoglycan-based hydrogels capture inflammatory chemokines and rescue defective wound healing in mice. Sci. Transl. Med. 9, eaai9044 (2017).
OpenUrl Abstract/FREE Full Text
1. J. C. Fischer,
2. M. Bscheider,
3. G. Eisenkolb,
4. C.-C. Lin,
5. A. Wintges,
6. V. Otten,
7. C. A. Lindemans,
8. S. Heidegger,
9. M. Rudelius,
10. S. Monette,
11. K. A. Porosnicu Rodriguez,
12. M. Calafiore,
13. S. Liebermann,
14. C. Liu,
15. S. Lienenklaus,
16. S. Weiss,
17. U. Kalinke,
18. J. Ruland,
19. C. Peschel,
20. Y. Shono,
21. M. Docampo,
22. E. Velardi,
23. R. R. Jenq,
24. A. M. Hanash,
25. J. A. Dudakov,
26. T. Haas,
27. M. R. M. van den Brink,
28. H. Poeck
, RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and immune-mediated tissue injury. Sci. Transl. Med. 9, eaag2513 (2017).
OpenUrl Abstract/FREE Full Text

This week’s articles describe a new hydrogel that promotes chronic wound healing and a way to limit intestinal tissue damage from radiation, chemo, or hematopoietic cell transplant therapies.

[1] N. Lohmann,
L. Schirmer,
P. Atallah,
E. Wandel,
R. A. Ferrer,
C. Werner,
J. C. Simon,
S. Franz,
U. Freudenberg
, Glycosaminoglycan-based hydrogels capture inflammatory chemokines and rescue defective wound healing in mice. Sci. Transl. Med. 9, eaai9044 (2017).
OpenUrl Abstract/FREE Full Text

[2] N. Lohmann,

[3] L. Schirmer,

[4] P. Atallah,

[5] E. Wandel,

[6] R. A. Ferrer,

[7] C. Werner,

[8] J. C. Simon,

[9] S. Franz,

[10] U. Freudenberg

[11] J. C. Fischer,
M. Bscheider,
G. Eisenkolb,
C.-C. Lin,
A. Wintges,
V. Otten,
C. A. Lindemans,
S. Heidegger,
M. Rudelius,
S. Monette,
K. A. Porosnicu Rodriguez,
M. Calafiore,
S. Liebermann,
C. Liu,
S. Lienenklaus,
S. Weiss,
U. Kalinke,
J. Ruland,
C. Peschel,
Y. Shono,
M. Docampo,
E. Velardi,
R. R. Jenq,
A. M. Hanash,
J. A. Dudakov,
T. Haas,
M. R. M. van den Brink,
H. Poeck
, RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and immune-mediated tissue injury. Sci. Transl. Med. 9, eaag2513 (2017).
OpenUrl Abstract/FREE Full Text

[12] J. C. Fischer,

[13] M. Bscheider,

[14] G. Eisenkolb,

[15] C.-C. Lin,

[16] A. Wintges,

[17] V. Otten,

[18] C. A. Lindemans,

[19] S. Heidegger,

[20] M. Rudelius,

[21] S. Monette,

[22] K. A. Porosnicu Rodriguez,

[23] M. Calafiore,

[24] S. Liebermann,

[25] C. Liu,

[26] S. Lienenklaus,

[27] S. Weiss,

[28] U. Kalinke,

[29] J. Ruland,

[30] C. Peschel,

[31] Y. Shono,

[32] M. Docampo,

[33] E. Velardi,

[34] R. R. Jenq,

[35] A. M. Hanash,

[36] J. A. Dudakov,

[37] T. Haas,

[38] M. R. M. van den Brink,

[39] H. Poeck

Papers of note in Science Translational Medicine 9 (386)

Highlighted Articles

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