Hyperactive locomotion in a Drosophila model is a functional readout for the synaptic abnormalities underlying fragile X syndrome

Risa Kashima; Patrick L. Redmond; Prajakta Ghatpande; Sougata Roy; Thomas B. Kornberg; Thomas Hanke; Stefan Knapp; Giorgio Lagna; Akiko Hata

doi:10.1126/scisignal.aai8133

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Hyperactive locomotion in a Drosophila model is a functional readout for the synaptic abnormalities underlying fragile X syndrome

View ORCID ProfileRisa Kashima¹,*,
View ORCID ProfilePatrick L. Redmond¹,*,
Prajakta Ghatpande¹,
View ORCID ProfileSougata Roy²,
View ORCID ProfileThomas B. Kornberg¹,
View ORCID ProfileThomas Hanke³,
View ORCID ProfileStefan Knapp³,⁴,
View ORCID ProfileGiorgio Lagna¹, and
View ORCID ProfileAkiko Hata¹,†

¹Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA.
²Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA.
³Institute of Pharmaceutical Chemistry and Buchmann Institute for Life Sciences, Goethe University, Frankfurt, Germany.
⁴Department of Clinical Medicine, Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, U.K.

↵†Corresponding author. Email: akiko.hata{at}ucsf.edu

↵* These authors contributed equally to this work.

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Science Signaling 02 May 2017:
Vol. 10, Issue 477, eaai8133
DOI: 10.1126/scisignal.aai8133

Risa Kashima

1Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA.

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Patrick L. Redmond

1Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA.

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Prajakta Ghatpande

1Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA.

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Sougata Roy

2Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA.

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Thomas B. Kornberg

1Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA.

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Thomas Hanke

3Institute of Pharmaceutical Chemistry and Buchmann Institute for Life Sciences, Goethe University, Frankfurt, Germany.

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Stefan Knapp

3Institute of Pharmaceutical Chemistry and Buchmann Institute for Life Sciences, Goethe University, Frankfurt, Germany.

4Department of Clinical Medicine, Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, U.K.

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Giorgio Lagna

1Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA.

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Akiko Hata

1Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA.

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For correspondence: akiko.hata@ucsf.edu

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