Editors' ChoiceCellular and Molecular Signaling

Papers of note in Science 356 (6336)

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Science Signaling  02 May 2017:
Vol. 10, Issue 477, eaan5373
DOI: 10.1126/scisignal.aan5373

This week’s articles highlight the importance of protocadherins in the developing nervous system and the mechanism by which plants limit the number of germ cells derived from somatic cells.


Pattern formation in the brain

Mountoufaris et al. used genetic approaches in mice to reveal the functional importance of the multicluster organization of mammalian protocadherin genes.

Chen et al. report that a protocadherin isoform mediates repulsion between serotonergic axon terminals to allow their tiled arrangements in target fields in mice.


Germ cells on demand

Zhao et al. found that cell cycle and transcription factors regulate the pathway that converts plant somatic cells into a limited number of germ cells (see also Vielle-Calzada).

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