Papers of note in Science Translational Medicine 9 (387)

Leslie K. Ferrarelli

doi:10.1126/scisignal.aan5399

This week’s articles reveal a new treatment for malaria and an adjunct therapy that may reduce the hematologic toxicity of chemotherapy.

MALARIA

A new antimalarial

Paquet et al. discover that an inhibitor of phosphatidylinositol 4-kinase may treat and prevent malaria.

CANCER

Rock-a-bye stem cells

He et al. show that inhibiting the kinases CDK4 and CDK6 may prevent chemotherapy-induced bone marrow toxicity and immunosuppression in cancer patients.

Highlighted Articles

1. T. Paquet,
2. C. Le Manach,
3. D. G. Cabrera,
4. Y. Younis,
5. P. P. Henrich,
6. T. S. Abraham,
7. M. C. S. Lee,
8. R. Basak,
9. S. Ghidelli-Disse,
10. M. J. Lafuente-Monasterio,
11. M. Bantscheff,
12. A. Ruecker,
13. A. M. Blagborough,
14. S. E. Zakutansky,
15. A.-M. Zeeman,
16. K. L. White,
17. D. M. Shackleford,
18. J. Mannila,
19. J. Morizzi,
20. C. Scheurer,
21. I. Angulo-Barturen,
22. M. S. Martínez,
23. S. Ferrer,
24. L. M. Sanz,
25. F. J. Gamo,
26. J. Reader,
27. M. Botha,
28. K. J. Dechering,
29. R. W. Sauerwein,
30. A. Tungtaeng,
31. P. Vanachayangkul,
32. C. S. Lim,
33. J. Burrows,
34. M. J. Witty,
35. K. C. Marsh,
36. C. Bodenreider,
37. R. Rochford,
38. S. M. Solapure,
39. M. B. Jiménez-Díaz,
40. S. Wittlin,
41. S. A. Charman,
42. C. Donini,
43. B. Campo,
44. L.-M. Birkholtz,
45. K. K. Hanson,
46. G. Drewes,
47. C. H. M. Kocken,
48. M. J. Delves,
49. D. Leroy,
50. D. A. Fidock,
51. D. Waterson,
52. L. J. Street,
53. K. Chibale
, Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase. Sci. Transl. Med. 9, eaad9735 (2017).
OpenUrl Abstract/FREE Full Text
1. S. He,
2. P. J. Roberts,
3. J. A. Sorrentino,
4. J. E. Bisi,
5. H. Storrie-White,
6. R. G. Tiessen,
7. K. M. Makhuli,
8. W. A. Wargin,
9. H. Tadema,
10. E.-J. van Hoogdalem,
11. J. C. Strum,
12. R. Malik,
13. N. E. Sharpless
, Transient CDK4/6 inhibition protects hematopoietic stem cells from chemotherapy-induced exhaustion. Sci. Transl. Med. 9, eaal3986 (2017).
OpenUrl Abstract/FREE Full Text

View Abstract

[1] T. Paquet,
C. Le Manach,
D. G. Cabrera,
Y. Younis,
P. P. Henrich,
T. S. Abraham,
M. C. S. Lee,
R. Basak,
S. Ghidelli-Disse,
M. J. Lafuente-Monasterio,
M. Bantscheff,
A. Ruecker,
A. M. Blagborough,
S. E. Zakutansky,
A.-M. Zeeman,
K. L. White,
D. M. Shackleford,
J. Mannila,
J. Morizzi,
C. Scheurer,
I. Angulo-Barturen,
M. S. Martínez,
S. Ferrer,
L. M. Sanz,
F. J. Gamo,
J. Reader,
M. Botha,
K. J. Dechering,
R. W. Sauerwein,
A. Tungtaeng,
P. Vanachayangkul,
C. S. Lim,
J. Burrows,
M. J. Witty,
K. C. Marsh,
C. Bodenreider,
R. Rochford,
S. M. Solapure,
M. B. Jiménez-Díaz,
S. Wittlin,
S. A. Charman,
C. Donini,
B. Campo,
L.-M. Birkholtz,
K. K. Hanson,
G. Drewes,
C. H. M. Kocken,
M. J. Delves,
D. Leroy,
D. A. Fidock,
D. Waterson,
L. J. Street,
K. Chibale
, Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase. Sci. Transl. Med. 9, eaad9735 (2017).
OpenUrl Abstract/FREE Full Text

[2] T. Paquet,

[3] C. Le Manach,

[4] D. G. Cabrera,

[5] Y. Younis,

[6] P. P. Henrich,

[7] T. S. Abraham,

[8] M. C. S. Lee,

[9] R. Basak,

[10] S. Ghidelli-Disse,

[11] M. J. Lafuente-Monasterio,

[12] M. Bantscheff,

[13] A. Ruecker,

[14] A. M. Blagborough,

[15] S. E. Zakutansky,

[16] A.-M. Zeeman,

[17] K. L. White,

[18] D. M. Shackleford,

[19] J. Mannila,

[20] J. Morizzi,

[21] C. Scheurer,

[22] I. Angulo-Barturen,

[23] M. S. Martínez,

[24] S. Ferrer,

[25] L. M. Sanz,

[26] F. J. Gamo,

[27] J. Reader,

[28] M. Botha,

[29] K. J. Dechering,

[30] R. W. Sauerwein,

[31] A. Tungtaeng,

[32] P. Vanachayangkul,

[33] C. S. Lim,

[34] J. Burrows,

[35] M. J. Witty,

[36] K. C. Marsh,

[37] C. Bodenreider,

[38] R. Rochford,

[39] S. M. Solapure,

[40] M. B. Jiménez-Díaz,

[41] S. Wittlin,

[42] S. A. Charman,

[43] C. Donini,

[44] B. Campo,

[45] L.-M. Birkholtz,

[46] K. K. Hanson,

[47] G. Drewes,

[48] C. H. M. Kocken,

[49] M. J. Delves,

[50] D. Leroy,

[51] D. A. Fidock,

[52] D. Waterson,

[53] L. J. Street,

[54] K. Chibale

[55] S. He,
P. J. Roberts,
J. A. Sorrentino,
J. E. Bisi,
H. Storrie-White,
R. G. Tiessen,
K. M. Makhuli,
W. A. Wargin,
H. Tadema,
E.-J. van Hoogdalem,
J. C. Strum,
R. Malik,
N. E. Sharpless
, Transient CDK4/6 inhibition protects hematopoietic stem cells from chemotherapy-induced exhaustion. Sci. Transl. Med. 9, eaal3986 (2017).
OpenUrl Abstract/FREE Full Text

[56] S. He,

[57] P. J. Roberts,

[58] J. A. Sorrentino,

[59] J. E. Bisi,

[60] H. Storrie-White,

[61] R. G. Tiessen,

[62] K. M. Makhuli,

[63] W. A. Wargin,

[64] H. Tadema,

[65] E.-J. van Hoogdalem,

[66] J. C. Strum,

[67] R. Malik,

[68] N. E. Sharpless

Papers of note in Science Translational Medicine 9 (387)

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