Tetraspanin microdomains control localized protein kinase C signaling in B cells

Malou Zuidscherwoude; Vera-Marie E. Dunlock; Geert van den Bogaart; Sjoerd J. van Deventer; Alie van der Schaaf; Jenny van Oostrum; Joachim Goedhart; Joanna In ‘t Hout; Günter J. Hämmerling; Satoshi Tanaka; André Nadler; Carsten Schultz; Mark D. Wright; Merel J. W. Adjobo-Hermans; Annemiek B. van Spriel

doi:10.1126/scisignal.aag2755

Research ArticleImmunology

Tetraspanin microdomains control localized protein kinase C signaling in B cells

View ORCID ProfileMalou Zuidscherwoude¹,*,
View ORCID ProfileVera-Marie E. Dunlock¹,*,
View ORCID ProfileGeert van den Bogaart¹,
Sjoerd J. van Deventer¹,
Alie van der Schaaf¹,
Jenny van Oostrum²,
View ORCID ProfileJoachim Goedhart³,
View ORCID ProfileJoanna In ‘t Hout⁴,
Günter J. Hämmerling⁵,
Satoshi Tanaka⁶,
André Nadler⁷,
Carsten Schultz⁸,
View ORCID ProfileMark D. Wright⁹,
View ORCID ProfileMerel J. W. Adjobo-Hermans², and
View ORCID ProfileAnnemiek B. van Spriel¹,†

¹Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.
²Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.
³Swammerdam Institute for Life Sciences, Section of Molecular Cytology, van Leeuwenhoek Centre for Advanced Microscopy, University of Amsterdam, 1098 XH Amsterdam, Netherlands.
⁴Department for Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Center, 6500 HB Nijmegen, Netherlands.
⁵Department of Molecular Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
⁶Department of Pathology, Sapporo Medical University School of Medicine, 060-8556 Sapporo, Japan.
⁷Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.
⁸Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.
⁹Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia.

↵†Corresponding author. Email: annemiek.vanspriel{at}radboudumc.nl

↵* These authors contributed equally to this work.

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Science Signaling 09 May 2017:
Vol. 10, Issue 478, eaag2755
DOI: 10.1126/scisignal.aag2755

Malou Zuidscherwoude

1Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.

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ORCID record for Malou Zuidscherwoude

Vera-Marie E. Dunlock

1Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.

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Geert van den Bogaart

1Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.

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Sjoerd J. van Deventer

1Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.

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Alie van der Schaaf

1Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.

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Jenny van Oostrum

2Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.

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Joachim Goedhart

3Swammerdam Institute for Life Sciences, Section of Molecular Cytology, van Leeuwenhoek Centre for Advanced Microscopy, University of Amsterdam, 1098 XH Amsterdam, Netherlands.

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Joanna In ‘t Hout

4Department for Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Center, 6500 HB Nijmegen, Netherlands.

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Günter J. Hämmerling

5Department of Molecular Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

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Satoshi Tanaka

6Department of Pathology, Sapporo Medical University School of Medicine, 060-8556 Sapporo, Japan.

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André Nadler

7Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.

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Carsten Schultz

8Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.

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Mark D. Wright

9Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia.

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Merel J. W. Adjobo-Hermans

2Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.

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Annemiek B. van Spriel

1Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.

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For correspondence: annemiek.vanspriel@radboudumc.nl

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