The amyloid-β oligomer Aβ*56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation

Fatou Amar; Mathew A. Sherman; Travis Rush; Megan Larson; Gabriel Boyle; Liu Chang; Jürgen Götz; Alain Buisson; Sylvain E. Lesné

doi:10.1126/scisignal.aal2021

Research ArticleAlzheimer’s Disease

The amyloid-β oligomer Aβ*56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation

View ORCID ProfileFatou Amar¹,²,³,*,
Mathew A. Sherman¹,²,³,
View ORCID ProfileTravis Rush⁴,†,
View ORCID ProfileMegan Larson¹,²,³,‡,
View ORCID ProfileGabriel Boyle¹,²,³,
View ORCID ProfileLiu Chang⁵,
Jürgen Götz⁶,
Alain Buisson⁴, and
View ORCID ProfileSylvain E. Lesné¹,²,³,§

¹Department of Neuroscience, University of Minnesota, Minneapolis, MN 55414, USA.
²N. Bud Grossman Center for Memory Research and Care, University of Minnesota, Minneapolis, MN 55414, USA.
³Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN 55414, USA.
⁴INSERM, U1216, Université Grenoble Alpes, Grenoble Institut des Neurosciences, BP 170, Grenoble Cedex 9, F-38042, France.
⁵Sydney Medical School, Brain and Mind Research Institute, University of Sydney, Camperdown, Sydney, New South Wales 2050, Australia.
⁶Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, University of Queensland, Brisbane, Queensland 4072, Australia.

↵§Corresponding author. Email: lesne002{at}umn.edu

↵* Present address: Taub Institute, Columbia University, New York, NY 10032, USA.
↵† Present address: Departments of Neurology and Neurobiology, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
↵‡ Present address: Bio-Techne, 614 McKinley Place Northeast, Minneapolis, MN 55413, USA.

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Science Signaling 09 May 2017:
Vol. 10, Issue 478, eaal2021
DOI: 10.1126/scisignal.aal2021

Fatou Amar

1Department of Neuroscience, University of Minnesota, Minneapolis, MN 55414, USA.

2N. Bud Grossman Center for Memory Research and Care, University of Minnesota, Minneapolis, MN 55414, USA.

3Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN 55414, USA.

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ORCID record for Fatou Amar

Mathew A. Sherman

1Department of Neuroscience, University of Minnesota, Minneapolis, MN 55414, USA.

2N. Bud Grossman Center for Memory Research and Care, University of Minnesota, Minneapolis, MN 55414, USA.

3Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN 55414, USA.

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Travis Rush

4INSERM, U1216, Université Grenoble Alpes, Grenoble Institut des Neurosciences, BP 170, Grenoble Cedex 9, F-38042, France.

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Megan Larson

1Department of Neuroscience, University of Minnesota, Minneapolis, MN 55414, USA.

2N. Bud Grossman Center for Memory Research and Care, University of Minnesota, Minneapolis, MN 55414, USA.

3Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN 55414, USA.

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Gabriel Boyle

1Department of Neuroscience, University of Minnesota, Minneapolis, MN 55414, USA.

2N. Bud Grossman Center for Memory Research and Care, University of Minnesota, Minneapolis, MN 55414, USA.

3Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN 55414, USA.

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Liu Chang

5Sydney Medical School, Brain and Mind Research Institute, University of Sydney, Camperdown, Sydney, New South Wales 2050, Australia.

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Jürgen Götz

6Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, University of Queensland, Brisbane, Queensland 4072, Australia.

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Alain Buisson

4INSERM, U1216, Université Grenoble Alpes, Grenoble Institut des Neurosciences, BP 170, Grenoble Cedex 9, F-38042, France.

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Sylvain E. Lesné

1Department of Neuroscience, University of Minnesota, Minneapolis, MN 55414, USA.

2N. Bud Grossman Center for Memory Research and Care, University of Minnesota, Minneapolis, MN 55414, USA.

3Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN 55414, USA.

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ORCID record for Sylvain E. Lesné
For correspondence: lesne002@umn.edu

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The amyloid-β oligomer Aβ*56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation

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