The amyloid-β oligomer Aβ*56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation

Fatou Amar; Mathew A. Sherman; Travis Rush; Megan Larson; Gabriel Boyle; Liu Chang; Jürgen Götz; Alain Buisson; Sylvain E. Lesné

doi:10.1126/scisignal.aal2021

Research ArticleAlzheimer’s Disease

The amyloid-β oligomer Aβ*56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation

Fatou Amar¹,²,³,*,
Mathew A. Sherman¹,²,³,
Travis Rush⁴,†,
Megan Larson¹,²,³,‡,
Gabriel Boyle¹,²,³,
Liu Chang⁵,
Jürgen Götz⁶,
Alain Buisson⁴, and
Sylvain E. Lesné¹,²,³,§

¹Department of Neuroscience, University of Minnesota, Minneapolis, MN 55414, USA.
²N. Bud Grossman Center for Memory Research and Care, University of Minnesota, Minneapolis, MN 55414, USA.
³Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN 55414, USA.
⁴INSERM, U1216, Université Grenoble Alpes, Grenoble Institut des Neurosciences, BP 170, Grenoble Cedex 9, F-38042, France.
⁵Sydney Medical School, Brain and Mind Research Institute, University of Sydney, Camperdown, Sydney, New South Wales 2050, Australia.
⁶Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, University of Queensland, Brisbane, Queensland 4072, Australia.

↵§Corresponding author. Email: lesne002{at}umn.edu

↵* Present address: Taub Institute, Columbia University, New York, NY 10032, USA.
↵† Present address: Departments of Neurology and Neurobiology, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
↵‡ Present address: Bio-Techne, 614 McKinley Place Northeast, Minneapolis, MN 55413, USA.

See allHide authors and affiliations

Science Signaling 09 May 2017:
Vol. 10, Issue 478, eaal2021
DOI: 10.1126/scisignal.aal2021

Fatou Amar

Department of Neuroscience, University of Minnesota, Minneapolis, MN 55414, USA.N. Bud Grossman Center for Memory Research and Care, University of Minnesota, Minneapolis, MN 55414, USA.Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN 55414, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Fatou Amar

Mathew A. Sherman

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Travis Rush

INSERM, U1216, Université Grenoble Alpes, Grenoble Institut des Neurosciences, BP 170, Grenoble Cedex 9, F-38042, France.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Travis Rush

Megan Larson

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Megan Larson

Gabriel Boyle

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Gabriel Boyle

Liu Chang

Sydney Medical School, Brain and Mind Research Institute, University of Sydney, Camperdown, Sydney, New South Wales 2050, Australia.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Liu Chang

Jürgen Götz

Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, University of Queensland, Brisbane, Queensland 4072, Australia.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Alain Buisson

INSERM, U1216, Université Grenoble Alpes, Grenoble Institut des Neurosciences, BP 170, Grenoble Cedex 9, F-38042, France.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Sylvain E. Lesné

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Sylvain E. Lesné
For correspondence: lesne002@umn.edu

Article
Figures & Data
Info & Metrics
eLetters
PDF

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. Please read our Terms of Service before submitting your own eLetter.

Submit a Response to This Article

Compose eLetter

Title

Contents

More information about text formats

Plain text

Plain text
No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First name and middle name First or given name, e.g. 'Peter'. Last Name Your last, or family, name, e.g. 'MacMoody'. Email Your email address, e.g. higgs-boson@gmail.com Role / Occupation Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests?

Yes

Please describe the competing interests

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

What code is in the image? Enter the characters shown in the image.

Vertical Tabs

No eLetters have been published for this article.

View Full Text

The amyloid-β oligomer Aβ*56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation

Plain text

Vertical Tabs

Science Signaling

Article Tools