Papers of note in Nature 545 (7652)

Annalisa M. VanHook

doi:10.1126/scisignal.aan5821

This week’s articles highlight a role for a polyglutamine tract in regulating autophagy; how cytokinesis affects the mechanosensitivity of cell junctions; the effect of interferon-γ on tumor vasculature; advances in human brain organoid technology; and biochemical features of a receptor that may aid in developing drugs that specifically target the receptor.

AUTOPHAGY

PolyQ promotes autophagy

Ashkenazi et al. found that the polyglutamine tract of ataxin 3 promotes autophagy by binding to and preventing degradation of beclin 1 (see also Martin and Hayden).

MECHANOTRANSDUCTION

Stretching promotes junction sensitivity

Pinheiro et al. showed that the pulling forces of cytokinesis stretch epithelial cell junctions, which causes a local reduction in E-cadherin and a subsequent increase in the mechanosensitivity of the junctions.

CANCER

Interfering with tumor vasculature

Kammertoens et al. demonstrated that interferon-γ promotes tumor cell necrosis by causing tumor-associated blood vessels to regress.

NEUROSCIENCE

Big leap for minibrains

Quadrato et al. and Birey et al. describe new methods for generating complex human brain organoids that replicate key features of neural development and even respond to sensory input (see also Camp and Treutlein).

STRUCTURAL BIOLOGY

Toward a selective PAR2 antagonist

Cheng et al. report on the structural and functional characteristics of agonist- and antagonist-bound forms of protease-activated receptor 2 (PAR2) that may help in developing drugs that target this receptor.

Highlighted Articles

1. A. Ashkenazi,
2. C. F. Bento,
3. T. Ricketts,
4. M. Vicinanza,
5. F. Siddiqi,
6. M. Pavel,
7. F. Squitieri,
8. M. C. Hardenberg,
9. S. Imarisio,
10. F. M. Menzies,
11. D. C. Rubinsztein
, Polyglutamine tracts regulate beclin 1-dependent autophagy. Nature 545, 108–111 (2017).
OpenUrl
1. D. D. O. Martin,
2. M. R. Hayden
, Role of repeats in protein clearance. Nature 545, 33–34 (2017).
OpenUrl
1. D. Pinheiro,
2. E. Hannezo,
3. S. Herszterg,
4. F. Bosveld,
5. I. Gaugue,
6. M. Balakireva,
7. Z. Wang,
8. I. Cristo,
9. S. U. Rigaud,
10. O. Markova,
11. Y. Bellaïche
, Transmission of cytokinesis forces via E-cadherin dilution and actomyosin flows. Nature 545, 103–107 (2017).
OpenUrl
1. T. Kammertoens,
2. C. Friese,
3. A. Arina,
4. C. Idel,
5. D. Briesemeister,
6. M. Rothe,
7. A. Ivanov,
8. A. Szymborska,
9. G. Patone,
10. S. Kunz,
11. D. Sommermeyer,
12. B. Engels,
13. M. Leisegang,
14. A. Textor,
15. H. J. Fehling,
16. M. Fruttiger,
17. M. Lohoff,
18. A. Herrmann,
19. H. Yu,
20. R. Weichselbaum,
21. W. Uckert,
22. N. Hübner,
23. H. Gerhardt,
24. D. Beule,
25. H. Schreiber,
26. T. Blankenstein
, Tumour ischaemia by interferon-γ resembles physiological blood vessel regression. Nature 545, 98–102 (2017).
OpenUrl
1. G. Quadrato,
2. T. Nguyen,
3. E. Z. Macosko,
4. J. L. Sherwood,
5. S. M. Yang,
6. D. R. Berger,
7. N. Maria,
8. J. Scholvin,
9. M. Goldman,
10. J. P. Kinney,
11. E. S. Boyden,
12. J. W. Lichtman,
13. Z. M. Williams,
14. S. A. McCarroll,
15. P. Arlotta
, Cell diversity and network dynamics in photosensitive human brain organoids. Nature 545, 48–53 (2017).
OpenUrl
1. F. Birey,
2. J. Andersen,
3. C. D. Makinson,
4. S. Islam,
5. W. Wei,
6. N. Huber,
7. H. C. Fan,
8. K. R. Cordes Metzler,
9. G. Panagiotakos,
10. N. Thom,
11. N. A. O’Rourke,
12. L. M. Steinmetz,
13. J. A. Bernstein,
14. J. Hallmayer,
15. J. R. Huguenard,
16. S. P. Paşca
, Assembly of functionally integrated human forebrain spheroids. Nature 545, 54–59 (2017).
OpenUrl
1. J. G. Camp,
2. B. Treutlein
, Advances in mini-brain technology. Nature 545, 39–40 (2017).
OpenUrl
1. R. K. Y. Cheng,
2. C. Fiez-Vandal,
3. O. Schlenker,
4. K. Edman,
5. B. Aggeler,
6. D. G. Brown,
7. G. A. Brown,
8. R. M. Cooke,
9. C. E. Dumelin,
10. A. S. Doré,
11. S. Geschwindner,
12. C. Grebner,
13. N.-O. Hermansson,
14. A. Jazayeri,
15. P. Johansson,
16. L. Leong,
17. R. Prihandoko,
18. M. Rappas,
19. H. Soutter,
20. A. Snijder,
21. L. Sundström,
22. B. Tehan,
23. P. Thornton,
24. D. Troast,
25. G. Wiggin,
26. A. Zhukov,
27. F. H. Marshall,
28. N. Dekker
, Structural insight into allosteric modulation of protease-activated receptor 2. Nature 545, 112–115 (2017).
OpenUrl

View Abstract

[1] A. Ashkenazi,
C. F. Bento,
T. Ricketts,
M. Vicinanza,
F. Siddiqi,
M. Pavel,
F. Squitieri,
M. C. Hardenberg,
S. Imarisio,
F. M. Menzies,
D. C. Rubinsztein
, Polyglutamine tracts regulate beclin 1-dependent autophagy. Nature 545, 108–111 (2017).
OpenUrl

[2] A. Ashkenazi,

[3] C. F. Bento,

[4] T. Ricketts,

[5] M. Vicinanza,

[6] F. Siddiqi,

[7] M. Pavel,

[8] F. Squitieri,

[9] M. C. Hardenberg,

[10] S. Imarisio,

[11] F. M. Menzies,

[12] D. C. Rubinsztein

[13] D. D. O. Martin,
M. R. Hayden
, Role of repeats in protein clearance. Nature 545, 33–34 (2017).
OpenUrl

[14] D. D. O. Martin,

[15] M. R. Hayden

[16] D. Pinheiro,
E. Hannezo,
S. Herszterg,
F. Bosveld,
I. Gaugue,
M. Balakireva,
Z. Wang,
I. Cristo,
S. U. Rigaud,
O. Markova,
Y. Bellaïche
, Transmission of cytokinesis forces via E-cadherin dilution and actomyosin flows. Nature 545, 103–107 (2017).
OpenUrl

[17] D. Pinheiro,

[18] E. Hannezo,

[19] S. Herszterg,

[20] F. Bosveld,

[21] I. Gaugue,

[22] M. Balakireva,

[23] Z. Wang,

[24] I. Cristo,

[25] S. U. Rigaud,

[26] O. Markova,

[27] Y. Bellaïche

[28] T. Kammertoens,
C. Friese,
A. Arina,
C. Idel,
D. Briesemeister,
M. Rothe,
A. Ivanov,
A. Szymborska,
G. Patone,
S. Kunz,
D. Sommermeyer,
B. Engels,
M. Leisegang,
A. Textor,
H. J. Fehling,
M. Fruttiger,
M. Lohoff,
A. Herrmann,
H. Yu,
R. Weichselbaum,
W. Uckert,
N. Hübner,
H. Gerhardt,
D. Beule,
H. Schreiber,
T. Blankenstein
, Tumour ischaemia by interferon-γ resembles physiological blood vessel regression. Nature 545, 98–102 (2017).
OpenUrl

[29] T. Kammertoens,

[30] C. Friese,

[31] A. Arina,

[32] C. Idel,

[33] D. Briesemeister,

[34] M. Rothe,

[35] A. Ivanov,

[36] A. Szymborska,

[37] G. Patone,

[38] S. Kunz,

[39] D. Sommermeyer,

[40] B. Engels,

[41] M. Leisegang,

[42] A. Textor,

[43] H. J. Fehling,

[44] M. Fruttiger,

[45] M. Lohoff,

[46] A. Herrmann,

[47] H. Yu,

[48] R. Weichselbaum,

[49] W. Uckert,

[50] N. Hübner,

[51] H. Gerhardt,

[52] D. Beule,

[53] H. Schreiber,

[54] T. Blankenstein

[55] G. Quadrato,
T. Nguyen,
E. Z. Macosko,
J. L. Sherwood,
S. M. Yang,
D. R. Berger,
N. Maria,
J. Scholvin,
M. Goldman,
J. P. Kinney,
E. S. Boyden,
J. W. Lichtman,
Z. M. Williams,
S. A. McCarroll,
P. Arlotta
, Cell diversity and network dynamics in photosensitive human brain organoids. Nature 545, 48–53 (2017).
OpenUrl

[56] G. Quadrato,

[57] T. Nguyen,

[58] E. Z. Macosko,

[59] J. L. Sherwood,

[60] S. M. Yang,

[61] D. R. Berger,

[62] N. Maria,

[63] J. Scholvin,

[64] M. Goldman,

[65] J. P. Kinney,

[66] E. S. Boyden,

[67] J. W. Lichtman,

[68] Z. M. Williams,

[69] S. A. McCarroll,

[70] P. Arlotta

[71] F. Birey,
J. Andersen,
C. D. Makinson,
S. Islam,
W. Wei,
N. Huber,
H. C. Fan,
K. R. Cordes Metzler,
G. Panagiotakos,
N. Thom,
N. A. O’Rourke,
L. M. Steinmetz,
J. A. Bernstein,
J. Hallmayer,
J. R. Huguenard,
S. P. Paşca
, Assembly of functionally integrated human forebrain spheroids. Nature 545, 54–59 (2017).
OpenUrl

[72] F. Birey,

[73] J. Andersen,

[74] C. D. Makinson,

[75] S. Islam,

[76] W. Wei,

[77] N. Huber,

[78] H. C. Fan,

[79] K. R. Cordes Metzler,

[80] G. Panagiotakos,

[81] N. Thom,

[82] N. A. O’Rourke,

[83] L. M. Steinmetz,

[84] J. A. Bernstein,

[85] J. Hallmayer,

[86] J. R. Huguenard,

[87] S. P. Paşca

[88] J. G. Camp,
B. Treutlein
, Advances in mini-brain technology. Nature 545, 39–40 (2017).
OpenUrl

[89] J. G. Camp,

[90] B. Treutlein

[91] R. K. Y. Cheng,
C. Fiez-Vandal,
O. Schlenker,
K. Edman,
B. Aggeler,
D. G. Brown,
G. A. Brown,
R. M. Cooke,
C. E. Dumelin,
A. S. Doré,
S. Geschwindner,
C. Grebner,
N.-O. Hermansson,
A. Jazayeri,
P. Johansson,
L. Leong,
R. Prihandoko,
M. Rappas,
H. Soutter,
A. Snijder,
L. Sundström,
B. Tehan,
P. Thornton,
D. Troast,
G. Wiggin,
A. Zhukov,
F. H. Marshall,
N. Dekker
, Structural insight into allosteric modulation of protease-activated receptor 2. Nature 545, 112–115 (2017).
OpenUrl

[92] R. K. Y. Cheng,

[93] C. Fiez-Vandal,

[94] O. Schlenker,

[95] K. Edman,

[96] B. Aggeler,

[97] D. G. Brown,

[98] G. A. Brown,

[99] R. M. Cooke,

[100] C. E. Dumelin,

[101] A. S. Doré,

[102] S. Geschwindner,

[103] C. Grebner,

[104] N.-O. Hermansson,

[105] A. Jazayeri,

[106] P. Johansson,

[107] L. Leong,

[108] R. Prihandoko,

[109] M. Rappas,

[110] H. Soutter,

[111] A. Snijder,

[112] L. Sundström,

[113] B. Tehan,

[114] P. Thornton,

[115] D. Troast,

[116] G. Wiggin,

[117] A. Zhukov,

[118] F. H. Marshall,

[119] N. Dekker

Papers of note in Nature 545 (7652)

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