Article Information
vol. 10 no. 479
PubMed:
Published By:
Print ISSN:
Online ISSN:
History:
- Received December 12, 2016
- Accepted April 25, 2017
- .
Copyright & Usage:
Copyright © 2017, American Association for the Advancement of Science
Research ArticleReproductive Biology
Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes
- Masahiro Nezu1,2,3,*,
- View ORCID ProfileTomokazu Souma1,2,4,*,
- Lei Yu1,
- View ORCID ProfileHiroki Sekine1,3,
- View ORCID ProfileNobuyuki Takahashi2,5,
- View ORCID ProfileAndrew Zu-Sern Wei4,
- Sadayoshi Ito2,
- View ORCID ProfileAkiyoshi Fukamizu6,
- View ORCID ProfileZsuzsanna K. Zsengeller7,8,
- Tomohiro Nakamura9,
- Atsushi Hozawa9,
- S. Ananth Karumanchi7,
- View ORCID ProfileNorio Suzuki3,†, and
- View ORCID ProfileMasayuki Yamamoto1,9,†
- 1Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.
- 2Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.
- 3Division of Oxygen Biology, United Centers for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.
- 4Division of Nephrology-Hypertension, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
- 5Division of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai 9808578, Japan.
- 6Life Science Center of Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba 3058577, Japan.
- 7Center for Vascular Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
- 8Radikal Therapeutics Inc., Beverly, MA 02575–1626, USA.
- 9Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Sendai 9808573, Japan.
- ↵†Corresponding author. Email: sunorio{at}med.tohoku.ac.jp (N.S.); masiyamamoto{at}med.tohoku.ac.jp (M.Y.)
↵* These authors contributed equally to this work.
See allHide authors and affiliations
Science Signaling 16 May 2017:
Vol. 10, Issue 479, eaam5711
DOI: 10.1126/scisignal.aam5711
Vol. 10, Issue 479, eaam5711
DOI: 10.1126/scisignal.aam5711
Masahiro Nezu
1Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.
2Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.
3Division of Oxygen Biology, United Centers for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.
Tomokazu Souma
1Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.
2Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.
4Division of Nephrology-Hypertension, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
Lei Yu
1Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.
Hiroki Sekine
1Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.
3Division of Oxygen Biology, United Centers for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.
Nobuyuki Takahashi
2Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.
5Division of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai 9808578, Japan.
Andrew Zu-Sern Wei
4Division of Nephrology-Hypertension, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
Sadayoshi Ito
2Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.
Akiyoshi Fukamizu
6Life Science Center of Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba 3058577, Japan.
Zsuzsanna K. Zsengeller
7Center for Vascular Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
8Radikal Therapeutics Inc., Beverly, MA 02575–1626, USA.
Tomohiro Nakamura
9Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Sendai 9808573, Japan.
Atsushi Hozawa
9Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Sendai 9808573, Japan.
S. Ananth Karumanchi
7Center for Vascular Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
Norio Suzuki
3Division of Oxygen Biology, United Centers for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.
Masayuki Yamamoto
1Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.
9Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Sendai 9808573, Japan.
