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vol. 10 no. 479
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- Received December 12, 2016
- Accepted April 25, 2017
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Copyright © 2017, American Association for the Advancement of Science
Research ArticleReproductive Biology
Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes
- Masahiro Nezu1,2,3,*,
- Tomokazu Souma1,2,4,*,
- Lei Yu1,
- Hiroki Sekine1,3,
- Nobuyuki Takahashi2,5,
- Andrew Zu-Sern Wei4,
- Sadayoshi Ito2,
- Akiyoshi Fukamizu6,
- Zsuzsanna K. Zsengeller7,8,
- Tomohiro Nakamura9,
- Atsushi Hozawa9,
- S. Ananth Karumanchi7,
- Norio Suzuki3,†, and
- Masayuki Yamamoto1,9,†
- 1Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.
- 2Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.
- 3Division of Oxygen Biology, United Centers for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.
- 4Division of Nephrology-Hypertension, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
- 5Division of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai 9808578, Japan.
- 6Life Science Center of Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba 3058577, Japan.
- 7Center for Vascular Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
- 8Radikal Therapeutics Inc., Beverly, MA 02575–1626, USA.
- 9Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Sendai 9808573, Japan.
- ↵†Corresponding author. Email: sunorio{at}med.tohoku.ac.jp (N.S.); masiyamamoto{at}med.tohoku.ac.jp (M.Y.)
↵* These authors contributed equally to this work.
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Science Signaling 16 May 2017:
Vol. 10, Issue 479, eaam5711
DOI: 10.1126/scisignal.aam5711
Vol. 10, Issue 479, eaam5711
DOI: 10.1126/scisignal.aam5711
Masahiro Nezu
Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.Division of Oxygen Biology, United Centers for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.
Tomokazu Souma
Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.Division of Nephrology-Hypertension, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
Lei Yu
Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.
Hiroki Sekine
Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.Division of Oxygen Biology, United Centers for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.
Nobuyuki Takahashi
Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.Division of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai 9808578, Japan.
Andrew Zu-Sern Wei
Division of Nephrology-Hypertension, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
Sadayoshi Ito
Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.
Akiyoshi Fukamizu
Life Science Center of Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba 3058577, Japan.
Zsuzsanna K. Zsengeller
Center for Vascular Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.Radikal Therapeutics Inc., Beverly, MA 02575–1626, USA.
Tomohiro Nakamura
Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Sendai 9808573, Japan.
Atsushi Hozawa
Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Sendai 9808573, Japan.
S. Ananth Karumanchi
Center for Vascular Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
Norio Suzuki
Division of Oxygen Biology, United Centers for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.
Masayuki Yamamoto
Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Sendai 9808573, Japan.
