Papers of note in Science 356 (6338)

Annalisa M. VanHook

doi:10.1126/scisignal.aan6391

This week’s articles demonstrate how T cells search for ligands; a role for the endoplasmic reticulum in the nonclathrin-mediated endocytosis of a growth factor receptor; and growth coupling between distant bacterial colonies that enables the cells to share limited resources.

IMMUNOLOGY

Search and capture in space and time

Cai et al. showed that T cells of the immune system palpate opposing cell surfaces in their search for ligands.

CELL BIOLOGY

ER-PM contacts in nonclathrin endocytosis

Caldieri et al. dissected an alternate mechanism for epidermal growth factor receptor endocytosis (see also Tan and Anderson).

SYSTEMS BIOLOGY

Maximizing growth by sharing

Liu et al. demonstrate how sharing resources can benefit bacterial colonies (see also Gordon).

Highlighted Articles

1. E. Cai,
2. K. Marchuk,
3. P. Beemiller,
4. C. Beppler,
5. M. G. Rubashkin,
6. V. M. Weaver,
7. A. Gérard,
8. T.-L. Liu,
9. B.-C. Chen,
10. E. Betzig,
11. F. Bartumeus,
12. M. F. Krummel
, Visualizing dynamic microvillar search and stabilization during ligand detection by T cells. Science 356, eaal3118 (2017).
OpenUrl Abstract/FREE Full Text
1. G. Caldieri,
2. E. Barbieri,
3. G. Nappo,
4. A. Raimondi,
5. M. Bonora,
6. A. Conte,
7. L. G. G. C. Verhoef,
8. S. Confalonieri,
9. M. G. Malabarba,
10. F. Bianchi,
11. A. Cuomo,
12. T. Bonaldi,
13. E. Martini,
14. D. Mazza,
15. P. Pinton,
16. C. Tacchetti,
17. S. Polo,
18. P. P. Di Fiore,
19. S. Sigismund
, Reticulon 3–dependent ER-PM contact sites control EGFR nonclathrin endocytosis. Science 356, 617–624 (2017).
OpenUrl Abstract/FREE Full Text
1. X. Tan,
2. R. A. Anderson
, Keeping in touch with the ER network. Science 356, 584–585 (2017).
OpenUrl Abstract/FREE Full Text
1. J. Liu,
2. R. Martinez-Corral,
3. A. Prindle,
4. D. D. Lee,
5. J. Larkin,
6. M. Gabalda-Sagarra,
7. J. Garcia-Ojalvo,
8. G. M. Süel
, Coupling between distant biofilms and emergence of nutrient time-sharing. Science 356, 638–642 (2017).
OpenUrl Abstract/FREE Full Text
1. V. Gordon
, Coupling and sharing when life is hard. Science 356, 583–584 (2017).
OpenUrl Abstract/FREE Full Text

View Abstract

[1] E. Cai,
K. Marchuk,
P. Beemiller,
C. Beppler,
M. G. Rubashkin,
V. M. Weaver,
A. Gérard,
T.-L. Liu,
B.-C. Chen,
E. Betzig,
F. Bartumeus,
M. F. Krummel
, Visualizing dynamic microvillar search and stabilization during ligand detection by T cells. Science 356, eaal3118 (2017).
OpenUrl Abstract/FREE Full Text

[2] E. Cai,

[3] K. Marchuk,

[4] P. Beemiller,

[5] C. Beppler,

[6] M. G. Rubashkin,

[7] V. M. Weaver,

[8] A. Gérard,

[9] T.-L. Liu,

[10] B.-C. Chen,

[11] E. Betzig,

[12] F. Bartumeus,

[13] M. F. Krummel

[14] G. Caldieri,
E. Barbieri,
G. Nappo,
A. Raimondi,
M. Bonora,
A. Conte,
L. G. G. C. Verhoef,
S. Confalonieri,
M. G. Malabarba,
F. Bianchi,
A. Cuomo,
T. Bonaldi,
E. Martini,
D. Mazza,
P. Pinton,
C. Tacchetti,
S. Polo,
P. P. Di Fiore,
S. Sigismund
, Reticulon 3–dependent ER-PM contact sites control EGFR nonclathrin endocytosis. Science 356, 617–624 (2017).
OpenUrl Abstract/FREE Full Text

[15] G. Caldieri,

[16] E. Barbieri,

[17] G. Nappo,

[18] A. Raimondi,

[19] M. Bonora,

[20] A. Conte,

[21] L. G. G. C. Verhoef,

[22] S. Confalonieri,

[23] M. G. Malabarba,

[24] F. Bianchi,

[25] A. Cuomo,

[26] T. Bonaldi,

[27] E. Martini,

[28] D. Mazza,

[29] P. Pinton,

[30] C. Tacchetti,

[31] S. Polo,

[32] P. P. Di Fiore,

[33] S. Sigismund

[34] X. Tan,
R. A. Anderson
, Keeping in touch with the ER network. Science 356, 584–585 (2017).
OpenUrl Abstract/FREE Full Text

[35] X. Tan,

[36] R. A. Anderson

[37] J. Liu,
R. Martinez-Corral,
A. Prindle,
D. D. Lee,
J. Larkin,
M. Gabalda-Sagarra,
J. Garcia-Ojalvo,
G. M. Süel
, Coupling between distant biofilms and emergence of nutrient time-sharing. Science 356, 638–642 (2017).
OpenUrl Abstract/FREE Full Text

[38] J. Liu,

[39] R. Martinez-Corral,

[40] A. Prindle,

[41] D. D. Lee,

[42] J. Larkin,

[43] M. Gabalda-Sagarra,

[44] J. Garcia-Ojalvo,

[45] G. M. Süel

[46] V. Gordon
, Coupling and sharing when life is hard. Science 356, 583–584 (2017).
OpenUrl Abstract/FREE Full Text

[47] V. Gordon

Papers of note in Science 356 (6338)

Highlighted Articles

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