Papers of note in Nature 545 (7653)

Annalisa M. VanHook

doi:10.1126/scisignal.aan6400

This week’s articles highlight colon cancer stem cells; cooperative signaling that maintains intestinal stem cell self-renewal; a newly developed Wnt agonist; and metabolic changes in endothelial cells that promote angiogenesis.

CANCER

Targeting colon cancer stem cells

Shimokawa et al. found that a specific subset of human colorectal cancer cells act as cancer stem cells and are targeted by combined chemotherapy.

PHARMACOLOGY

Functional Wnt agonists

Janda et al. developed agonists that stimulate Wnt signaling by forcing its receptor and co-receptor to heterodimerize in the absence of ligand.

STEM CELLS

Cooperation between Wnts and R-spondins

Yan et al. found that Wnt and R-spondin cooperate to control intestinal stem cell self-renewal but are not redundant.

VASCULAR BIOLOGY

FGF signaling and cellular metabolism

Yu et al. showed that FGF signaling promotes angiogenesis by stimulating glycolysis in endothelial cells.

Highlighted Articles

1. M. Shimokawa,
2. Y. Ohta,
3. S. Nishikori,
4. M. Matano,
5. A. Takano,
6. M. Fujii,
7. S. Date,
8. S. Sugimoto,
9. T. Kanai,
10. T. Sato
, Visualization and targeting of LGR5⁺ human colon cancer stem cells. Nature 545, 187–192 (2017).
OpenUrl
1. C. Y. Janda,
2. L. T. Dang,
3. C. You,
4. J. Chang,
5. W. de Lau,
6. Z. A. Zhong,
7. K. S. Yan,
8. O. Marecic,
9. D. Siepe,
10. X. Li,
11. J. D. Moody,
12. B. O. Williams,
13. H. Clevers,
14. J. Piehler,
15. D. Baker,
16. C. J. Kuo,
17. K. C. Garcia
, Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling. Nature 545, 234–237 (2017).
OpenUrl
1. K. S. Yan,
2. C. Y. Janda,
3. J. Chang,
4. G. X. Y. Zheng,
5. K. A. Larkin,
6. V. C. Luca,
7. L. A. Chia,
8. A. T. Mah,
9. A. Han,
10. J. M. Terry,
11. A. Ootani,
12. K. Roelf,
13. M. Lee,
14. J. Yuan,
15. X. Li,
16. C. R. Bolen,
17. J. Wilhelmy,
18. P. S. Davies,
19. H. Ueno,
20. R. J. von Furstenberg,
21. P. Belgrader,
22. S. B. Ziraldo,
23. H. Ordonez,
24. S. J. Henning,
25. M. H. Wong,
26. M. P. Snyder,
27. I. L. Weissman,
28. A. J. Hsueh,
29. T. S. Mikkelsen,
30. K. C. Garcia,
31. C. J. Kuo
, Non-equivalence of Wnt and R-spondin ligands during Lgr5⁺ intestinal stem-cell self-renewal. Nature 545, 238–242 (2017).
OpenUrl
1. P. Yu,
2. K. Wilhelm,
3. A. Dubrac,
4. J. K. Tung,
5. T. C. Alves,
6. J. S. Fang,
7. Y. Xie,
8. J. Zhu,
9. Z. Chen,
10. F. De Smet,
11. J. Zhang,
12. S.-W. Jin,
13. L. Sun,
14. H. Sun,
15. R. G. Kibbey,
16. K. K. Hirschi,
17. N. Hay,
18. P. Carmeliet,
19. T. W. Chittenden,
20. A. Eichmann,
21. M. Potente,
22. M. Simons
, FGF-dependent metabolic control of vascular development. Nature 545, 224–228 (2017).
OpenUrl

View Abstract

[1] M. Shimokawa,
Y. Ohta,
S. Nishikori,
M. Matano,
A. Takano,
M. Fujii,
S. Date,
S. Sugimoto,
T. Kanai,
T. Sato
, Visualization and targeting of LGR5⁺ human colon cancer stem cells. Nature 545, 187–192 (2017).
OpenUrl

[2] M. Shimokawa,

[3] Y. Ohta,

[4] S. Nishikori,

[5] M. Matano,

[6] A. Takano,

[7] M. Fujii,

[8] S. Date,

[9] S. Sugimoto,

[10] T. Kanai,

[11] T. Sato

[12] C. Y. Janda,
L. T. Dang,
C. You,
J. Chang,
W. de Lau,
Z. A. Zhong,
K. S. Yan,
O. Marecic,
D. Siepe,
X. Li,
J. D. Moody,
B. O. Williams,
H. Clevers,
J. Piehler,
D. Baker,
C. J. Kuo,
K. C. Garcia
, Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling. Nature 545, 234–237 (2017).
OpenUrl

[13] C. Y. Janda,

[14] L. T. Dang,

[15] C. You,

[16] J. Chang,

[17] W. de Lau,

[18] Z. A. Zhong,

[19] K. S. Yan,

[20] O. Marecic,

[21] D. Siepe,

[22] X. Li,

[23] J. D. Moody,

[24] B. O. Williams,

[25] H. Clevers,

[26] J. Piehler,

[27] D. Baker,

[28] C. J. Kuo,

[29] K. C. Garcia

[30] K. S. Yan,
C. Y. Janda,
J. Chang,
G. X. Y. Zheng,
K. A. Larkin,
V. C. Luca,
L. A. Chia,
A. T. Mah,
A. Han,
J. M. Terry,
A. Ootani,
K. Roelf,
M. Lee,
J. Yuan,
X. Li,
C. R. Bolen,
J. Wilhelmy,
P. S. Davies,
H. Ueno,
R. J. von Furstenberg,
P. Belgrader,
S. B. Ziraldo,
H. Ordonez,
S. J. Henning,
M. H. Wong,
M. P. Snyder,
I. L. Weissman,
A. J. Hsueh,
T. S. Mikkelsen,
K. C. Garcia,
C. J. Kuo
, Non-equivalence of Wnt and R-spondin ligands during Lgr5⁺ intestinal stem-cell self-renewal. Nature 545, 238–242 (2017).
OpenUrl

[31] K. S. Yan,

[32] C. Y. Janda,

[33] J. Chang,

[34] G. X. Y. Zheng,

[35] K. A. Larkin,

[36] V. C. Luca,

[37] L. A. Chia,

[38] A. T. Mah,

[39] A. Han,

[40] J. M. Terry,

[41] A. Ootani,

[42] K. Roelf,

[43] M. Lee,

[44] J. Yuan,

[45] X. Li,

[46] C. R. Bolen,

[47] J. Wilhelmy,

[48] P. S. Davies,

[49] H. Ueno,

[50] R. J. von Furstenberg,

[51] P. Belgrader,

[52] S. B. Ziraldo,

[53] H. Ordonez,

[54] S. J. Henning,

[55] M. H. Wong,

[56] M. P. Snyder,

[57] I. L. Weissman,

[58] A. J. Hsueh,

[59] T. S. Mikkelsen,

[60] K. C. Garcia,

[61] C. J. Kuo

[62] P. Yu,
K. Wilhelm,
A. Dubrac,
J. K. Tung,
T. C. Alves,
J. S. Fang,
Y. Xie,
J. Zhu,
Z. Chen,
F. De Smet,
J. Zhang,
S.-W. Jin,
L. Sun,
H. Sun,
R. G. Kibbey,
K. K. Hirschi,
N. Hay,
P. Carmeliet,
T. W. Chittenden,
A. Eichmann,
M. Potente,
M. Simons
, FGF-dependent metabolic control of vascular development. Nature 545, 224–228 (2017).
OpenUrl

[63] P. Yu,

[64] K. Wilhelm,

[65] A. Dubrac,

[66] J. K. Tung,

[67] T. C. Alves,

[68] J. S. Fang,

[69] Y. Xie,

[70] J. Zhu,

[71] Z. Chen,

[72] F. De Smet,

[73] J. Zhang,

[74] S.-W. Jin,

[75] L. Sun,

[76] H. Sun,

[77] R. G. Kibbey,

[78] K. K. Hirschi,

[79] N. Hay,

[80] P. Carmeliet,

[81] T. W. Chittenden,

[82] A. Eichmann,

[83] M. Potente,

[84] M. Simons

Papers of note in Nature 545 (7653)

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