Contents
23 May 2017
Vol 10, Issue 480
Vol 10, Issue 480
Research Articles
- Androgen receptor inhibitor–induced “BRCAness” and PARP inhibition are synthetically lethal for castration-resistant prostate cancer
Androgen receptor inhibition induces a “BRCAness” state that may be exploited with PARP inhibitors in patients with advanced prostate cancer.
- Key determinants of selective binding and activation by the monocyte chemoattractant proteins at the chemokine receptor CCR2
Structure-function analysis of chemokines and their shared receptor may aid in the development of small-molecule inhibitors.
- A cryo-EM–based model of phosphorylation- and FKBP12.6-mediated allosterism of the cardiac ryanodine receptor
Conformational rigidity of the cardiac intracellular Ca2+ channel RyR2 may be enhanced by FKBP12.6 binding and reduced by phosphorylation.
Editors' Choice
- Receptor cooperation in B cells
TLR4-stimulated B cell activation is mediated by the tyrosine kinase Syk and depends on the B cell receptor.
- New connections: How to become more flexible and open up
Cryo-EM–generated structures provide insight into how RyR2 is gated and how phosphorylation may affect the activation process.
- Papers of note in Science 356 (6339)
This week’s articles identify a repulsive guidance system that controls the recruitment of T cells to germinal centers; a mechanism for controlling the transfer of nutrients from the placenta to early mouse embryos; and the subcellular location of calcium dynamics in astrocytes.
- Papers of note in Science Translational Medicine 9 (390)
This week’s articles describe new treatments for heart failure and its associated symptoms and a sequential gene delivery system to regenerate fractured bone.
- Papers of note in Nature 545 (7654)
This week’s articles highlight plant growth responses to nutrients; axonal pathfinding; an unexpected source of tumor niche cells; photosensation in the fly brain; the selectivity of GPCRs for specific G proteins; balancing mTORC signaling; and a connection between gut microbes and brain vasculature malformations.
About The Cover
Online Cover This week features a Research Article that shows how androgen receptor inhibition induces a "BRCAness" state that may be exploited with PARP inhibitors in patients with advanced prostate cancer. The findings potentially expand the clinical utility of PARP inhibitors to tumors lacking BRCA mutations. [Image: hidesy/istockphoto]