Article Information
vol. 10 no. 480
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History:
- Received August 22, 2016
- Accepted May 5, 2017
- .
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Copyright © 2017, American Association for the Advancement of Science
Research ArticleBiochemistry
Key determinants of selective binding and activation by the monocyte chemoattractant proteins at the chemokine receptor CCR2
- View ORCID ProfileZil E. Huma1,
- Julie Sanchez1,
- Herman D. Lim2,
- View ORCID ProfileJessica L. Bridgford1,2,
- View ORCID ProfileCheng Huang1,
- View ORCID ProfileBradyn J. Parker1,
- View ORCID ProfileJiann G. Pazhamalil1,
- Benjamin T. Porebski1,
- Kevin D. G. Pfleger3,
- View ORCID ProfileJ. Robert Lane2,
- View ORCID ProfileMeritxell Canals2,*, and
- View ORCID ProfileMartin J. Stone1,*
- 1Infection and Immunity Program, Monash Biomedicine Discovery Institute, and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.
- 2Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
- 3Molecular Endocrinology and Pharmacology, Harry Perkins Institute of Medical Research, QEII Medical Centre; and Centre for Medical Research, University of Western Australia, Crawley and Dimerix Bioscience Limited, Nedlands, Western Australia, Australia.
- ↵*Corresponding author. Email: martin.stone{at}monash.edu (M.J.S.); meri.canals{at}monash.edu (M.C.)
See allHide authors and affiliations
Science Signaling 23 May 2017:
Vol. 10, Issue 480, eaai8529
DOI: 10.1126/scisignal.aai8529
Vol. 10, Issue 480, eaai8529
DOI: 10.1126/scisignal.aai8529
Zil E. Huma
1Infection and Immunity Program, Monash Biomedicine Discovery Institute, and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.
Julie Sanchez
1Infection and Immunity Program, Monash Biomedicine Discovery Institute, and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.
Herman D. Lim
2Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Jessica L. Bridgford
1Infection and Immunity Program, Monash Biomedicine Discovery Institute, and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.
2Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Cheng Huang
1Infection and Immunity Program, Monash Biomedicine Discovery Institute, and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.
Bradyn J. Parker
1Infection and Immunity Program, Monash Biomedicine Discovery Institute, and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.
Jiann G. Pazhamalil
1Infection and Immunity Program, Monash Biomedicine Discovery Institute, and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.
Benjamin T. Porebski
1Infection and Immunity Program, Monash Biomedicine Discovery Institute, and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.
Kevin D. G. Pfleger
3Molecular Endocrinology and Pharmacology, Harry Perkins Institute of Medical Research, QEII Medical Centre; and Centre for Medical Research, University of Western Australia, Crawley and Dimerix Bioscience Limited, Nedlands, Western Australia, Australia.
J. Robert Lane
2Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Meritxell Canals
2Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Martin J. Stone
1Infection and Immunity Program, Monash Biomedicine Discovery Institute, and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.
