Key determinants of selective binding and activation by the monocyte chemoattractant proteins at the chemokine receptor CCR2

Zil E. Huma; Julie Sanchez; Herman D. Lim; Jessica L. Bridgford; Cheng Huang; Bradyn J. Parker; Jiann G. Pazhamalil; Benjamin T. Porebski; Kevin D. G. Pfleger; J. Robert Lane; Meritxell Canals; Martin J. Stone

doi:10.1126/scisignal.aai8529

Research ArticleBiochemistry

Key determinants of selective binding and activation by the monocyte chemoattractant proteins at the chemokine receptor CCR2

View ORCID ProfileZil E. Huma¹,
Julie Sanchez¹,
Herman D. Lim²,
View ORCID ProfileJessica L. Bridgford¹,²,
View ORCID ProfileCheng Huang¹,
View ORCID ProfileBradyn J. Parker¹,
View ORCID ProfileJiann G. Pazhamalil¹,
Benjamin T. Porebski¹,
Kevin D. G. Pfleger³,
View ORCID ProfileJ. Robert Lane²,
View ORCID ProfileMeritxell Canals²,*, and
View ORCID ProfileMartin J. Stone¹,*

¹Infection and Immunity Program, Monash Biomedicine Discovery Institute, and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.
²Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
³Molecular Endocrinology and Pharmacology, Harry Perkins Institute of Medical Research, QEII Medical Centre; and Centre for Medical Research, University of Western Australia, Crawley and Dimerix Bioscience Limited, Nedlands, Western Australia, Australia.

↵*Corresponding author. Email: martin.stone{at}monash.edu (M.J.S.); meri.canals{at}monash.edu (M.C.)

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Science Signaling 23 May 2017:
Vol. 10, Issue 480, eaai8529
DOI: 10.1126/scisignal.aai8529

Zil E. Huma

1Infection and Immunity Program, Monash Biomedicine Discovery Institute, and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.

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ORCID record for Zil E. Huma

Julie Sanchez

1Infection and Immunity Program, Monash Biomedicine Discovery Institute, and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.

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Herman D. Lim

2Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

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Jessica L. Bridgford

1Infection and Immunity Program, Monash Biomedicine Discovery Institute, and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.

2Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

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ORCID record for Jessica L. Bridgford

Cheng Huang

1Infection and Immunity Program, Monash Biomedicine Discovery Institute, and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.

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ORCID record for Cheng Huang

Bradyn J. Parker

1Infection and Immunity Program, Monash Biomedicine Discovery Institute, and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.

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Jiann G. Pazhamalil

1Infection and Immunity Program, Monash Biomedicine Discovery Institute, and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.

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Benjamin T. Porebski

1Infection and Immunity Program, Monash Biomedicine Discovery Institute, and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.

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Kevin D. G. Pfleger

3Molecular Endocrinology and Pharmacology, Harry Perkins Institute of Medical Research, QEII Medical Centre; and Centre for Medical Research, University of Western Australia, Crawley and Dimerix Bioscience Limited, Nedlands, Western Australia, Australia.

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J. Robert Lane

2Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

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Meritxell Canals

2Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

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For correspondence: martin.stone@monash.edu meri.canals@monash.edu

Martin J. Stone

1Infection and Immunity Program, Monash Biomedicine Discovery Institute, and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.

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ORCID record for Martin J. Stone
For correspondence: martin.stone@monash.edu meri.canals@monash.edu

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