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Papers of note in Science Translational Medicine 9 (390)

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Science Signaling  23 May 2017:
Vol. 10, Issue 480, eaan6824
DOI: 10.1126/scisignal.aan6824

This week’s articles describe new treatments for heart failure and its associated symptoms and a sequential gene delivery system to regenerate fractured bone.


BETting on a new heart failure treatment

Duan et al. found that inhibiting the epigenetic “reader” BRD4 treats heart failure by blocking the induction of innate inflammatory and profibrotic gene networks.

A brainy treatment for heart failure

Foster et al. show that inhibiting β-adrenergic signaling in the brain may restore respiratory function and prevent diaphragm atrophy in heart failure.


Bubbles and BMP-6 for bone repair

Bez et al. developed a two-step therapy to treat bone fractures by first implanting a collagen sponge at the fracture site that recruited progenitor cells and then injecting DNA encoding bone morphogenetic protein-6 (BMP-6) along with microbubbles that helped the progenitor cells take up BMP-6.

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