Papers of note in Science Translational Medicine 9 (390)

Leslie K. Ferrarelli

doi:10.1126/scisignal.aan6824

This week’s articles describe new treatments for heart failure and its associated symptoms and a sequential gene delivery system to regenerate fractured bone.

HEART FAILURE

BETting on a new heart failure treatment

Duan et al. found that inhibiting the epigenetic “reader” BRD4 treats heart failure by blocking the induction of innate inflammatory and profibrotic gene networks.

A brainy treatment for heart failure

Foster et al. show that inhibiting β-adrenergic signaling in the brain may restore respiratory function and prevent diaphragm atrophy in heart failure.

BONE REGENERATION

Bubbles and BMP-6 for bone repair

Bez et al. developed a two-step therapy to treat bone fractures by first implanting a collagen sponge at the fracture site that recruited progenitor cells and then injecting DNA encoding bone morphogenetic protein-6 (BMP-6) along with microbubbles that helped the progenitor cells take up BMP-6.

Highlighted Articles

1. Q. Duan,
2. S. McMahon,
3. P. Anand,
4. H. Shah,
5. S. Thomas,
6. H. T. Salunga,
7. Y. Huang,
8. R. Zhang,
9. A. Sahadevan,
10. M. E. Lemieux,
11. J. D. Brown,
12. D. Srivastava,
13. J. E. Bradner,
14. T. A. McKinsey,
15. S. M. Haldar
, BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure. Sci. Transl. Med. 9, eaah5084 (2017).
OpenUrl Abstract/FREE Full Text
1. A. J. Foster,
2. M. J. Platt,
3. J. S. Huber,
4. A. L. Eadie,
5. A. M. Arkell,
6. N. Romanova,
7. D. C. Wright,
8. T. E. Gillis,
9. C. L. Murrant,
10. K. R. Brunt,
11. J. A. Simpson
, Central-acting therapeutics alleviate respiratory weakness caused by heart failure–induced ventilatory overdrive. Sci. Transl. Med. 9, eaag1303 (2017).
OpenUrl Abstract/FREE Full Text
1. M. Bez,
2. D. Sheyn,
3. W. Tawackoli,
4. P. Avalos,
5. G. Shapiro,
6. J. C. Giaconi,
7. X. Da,
8. S. Ben David,
9. J. Gavrity,
10. H. A. Awad,
11. H. W. Bae,
12. E. J. Ley,
13. T. J. Kremen,
14. Z. Gazit,
15. K. W. Ferrara,
16. G. Pelled,
17. D. Gazit
, In situ bone tissue engineering via ultrasound-mediated gene delivery to endogenous progenitor cells in mini-pigs. Sci. Transl. Med. 9, eaal3128 (2017).
OpenUrl Abstract/FREE Full Text

View Abstract

This week’s articles describe new treatments for heart failure and its associated symptoms and a sequential gene delivery system to regenerate fractured bone.

[1] Q. Duan,
S. McMahon,
P. Anand,
H. Shah,
S. Thomas,
H. T. Salunga,
Y. Huang,
R. Zhang,
A. Sahadevan,
M. E. Lemieux,
J. D. Brown,
D. Srivastava,
J. E. Bradner,
T. A. McKinsey,
S. M. Haldar
, BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure. Sci. Transl. Med. 9, eaah5084 (2017).
OpenUrl Abstract/FREE Full Text

[2] Q. Duan,

[3] S. McMahon,

[4] P. Anand,

[5] H. Shah,

[6] S. Thomas,

[7] H. T. Salunga,

[8] Y. Huang,

[9] R. Zhang,

[10] A. Sahadevan,

[11] M. E. Lemieux,

[12] J. D. Brown,

[13] D. Srivastava,

[14] J. E. Bradner,

[15] T. A. McKinsey,

[16] S. M. Haldar

[17] A. J. Foster,
M. J. Platt,
J. S. Huber,
A. L. Eadie,
A. M. Arkell,
N. Romanova,
D. C. Wright,
T. E. Gillis,
C. L. Murrant,
K. R. Brunt,
J. A. Simpson
, Central-acting therapeutics alleviate respiratory weakness caused by heart failure–induced ventilatory overdrive. Sci. Transl. Med. 9, eaag1303 (2017).
OpenUrl Abstract/FREE Full Text

[18] A. J. Foster,

[19] M. J. Platt,

[20] J. S. Huber,

[21] A. L. Eadie,

[22] A. M. Arkell,

[23] N. Romanova,

[24] D. C. Wright,

[25] T. E. Gillis,

[26] C. L. Murrant,

[27] K. R. Brunt,

[28] J. A. Simpson

[29] M. Bez,
D. Sheyn,
W. Tawackoli,
P. Avalos,
G. Shapiro,
J. C. Giaconi,
X. Da,
S. Ben David,
J. Gavrity,
H. A. Awad,
H. W. Bae,
E. J. Ley,
T. J. Kremen,
Z. Gazit,
K. W. Ferrara,
G. Pelled,
D. Gazit
, In situ bone tissue engineering via ultrasound-mediated gene delivery to endogenous progenitor cells in mini-pigs. Sci. Transl. Med. 9, eaal3128 (2017).
OpenUrl Abstract/FREE Full Text

[30] M. Bez,

[31] D. Sheyn,

[32] W. Tawackoli,

[33] P. Avalos,

[34] G. Shapiro,

[35] J. C. Giaconi,

[36] X. Da,

[37] S. Ben David,

[38] J. Gavrity,

[39] H. A. Awad,

[40] H. W. Bae,

[41] E. J. Ley,

[42] T. J. Kremen,

[43] Z. Gazit,

[44] K. W. Ferrara,

[45] G. Pelled,

[46] D. Gazit

Papers of note in Science Translational Medicine 9 (390)

Highlighted Articles

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