Contents
30 May 2017
Vol 10, Issue 481
Vol 10, Issue 481
Research Articles
- A disease-linked ULBP6 polymorphism inhibits NKG2D-mediated target cell killing by enhancing the stability of NKG2D ligand binding
A disease-associated variant of an activating ligand engages receptors so strongly that it impairs NK cell–mediated killing.
- T-plastin is essential for basement membrane assembly and epidermal morphogenesis
The actin-bundling protein T-plastin and the cortical cytoskeleton ensure that the epidermal basement membrane develops properly.
Editors' Choice
- A little stress is good
Acute psychological stress triggers signaling between sympathetic neurons and the spleen to protect against ischemic tissue damage.
- New connections: Manipulating NK cell responses
Manipulating ligand interactions with the activating receptor NKG2D modulates natural killer cell responses.
- Papers of note in Science 356 (6340)
This week’s articles highlight new research that identifies a microRNA decay pathway that promotes cell cycle progression; an interactive atlas of the subcellular localization of thousands of human proteins, which may help refine signaling networks; and a review of symbiotic plant-microbe interactions.
- Papers of note in Science Translational Medicine 9 (391)
This week’s articles describe a way in which brain metastases can trigger drug resistance in primary breast tumors and a potential therapy for ALS.
- Papers of note in Nature 545 (7655)
This week’s articles focus on cancer immunotherapy, the plant immune response, and the human protein interactome.
Erratum
- Erratum for the Research Article: “The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response” by T. Okazaki, M. Higuchi, K. Takeda, K. Iwatsuki-Horimoto, M. Kiso, M. Miyagishi, H. Yanai, A. Kato, M. Yoneyama, T. Fujita, T. Taniguchi, Y. Kawaoka, H. Ichijo, Y. Gotoh
Several oligonucleotide sequences listed in the Materials and Methods are corrected.
About The Cover
Online Cover This week features a Research Article that describes how a disease-associated variant of an activating ligand engages receptors so strongly that it impairs natural killer cell–mediated killing. The image shows a natural killer cell attacking an ependymoma cancer cell. [Image: Eye of Science/Science Source]