A disease-linked ULBP6 polymorphism inhibits NKG2D-mediated target cell killing by enhancing the stability of NKG2D ligand binding

Jianmin Zuo; Carrie R. Willcox; Fiyaz Mohammed; Martin Davey; Stuart Hunter; Kabir Khan; Ayman Antoun; Poonam Katakia; Joanne Croudace; Charlotte Inman; Helen Parry; David Briggs; Ram Malladi; Benjamin E. Willcox; Paul Moss

doi:10.1126/scisignal.aai8904

Research ArticleImmunology

A disease-linked ULBP6 polymorphism inhibits NKG2D-mediated target cell killing by enhancing the stability of NKG2D ligand binding

Jianmin Zuo¹,*,
Carrie R. Willcox¹,*,
Fiyaz Mohammed¹,*,
Martin Davey¹,
Stuart Hunter¹,
Kabir Khan¹,
Ayman Antoun¹,†,
Poonam Katakia¹,
Joanne Croudace¹,
Charlotte Inman¹,
Helen Parry¹,²,
David Briggs³,
Ram Malladi¹,²,
Benjamin E. Willcox¹,*,‡, and
Paul Moss¹,²,*,‡

¹Cancer Immunology and Immunotherapy Centre, Institute of Immunology and Immunotherapy, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT, UK.
²Department of Haematology, University Hospital Birmingham, Birmingham B15 2TH, UK.
³National Health Service Blood and Transplant, Birmingham B15 2SG, UK.

↵‡Corresponding author. Email: p.moss{at}bham.ac.uk (P.M.); b.willcox{at}bham.ac.uk (B.E.W.)

↵* These authors contributed equally to this work.
↵† Present address: School of Pharmacy, Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton WV1 1LY, UK.

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Science Signaling 30 May 2017:
Vol. 10, Issue 481, eaai8904
DOI: 10.1126/scisignal.aai8904

Jianmin Zuo

1Cancer Immunology and Immunotherapy Centre, Institute of Immunology and Immunotherapy, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT, UK.

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Carrie R. Willcox

1Cancer Immunology and Immunotherapy Centre, Institute of Immunology and Immunotherapy, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT, UK.

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Fiyaz Mohammed

1Cancer Immunology and Immunotherapy Centre, Institute of Immunology and Immunotherapy, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT, UK.

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Martin Davey

1Cancer Immunology and Immunotherapy Centre, Institute of Immunology and Immunotherapy, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT, UK.

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Stuart Hunter

1Cancer Immunology and Immunotherapy Centre, Institute of Immunology and Immunotherapy, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT, UK.

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Kabir Khan

1Cancer Immunology and Immunotherapy Centre, Institute of Immunology and Immunotherapy, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT, UK.

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Ayman Antoun

1Cancer Immunology and Immunotherapy Centre, Institute of Immunology and Immunotherapy, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT, UK.

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Poonam Katakia

1Cancer Immunology and Immunotherapy Centre, Institute of Immunology and Immunotherapy, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT, UK.

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Joanne Croudace

1Cancer Immunology and Immunotherapy Centre, Institute of Immunology and Immunotherapy, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT, UK.

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Charlotte Inman

1Cancer Immunology and Immunotherapy Centre, Institute of Immunology and Immunotherapy, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT, UK.

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Helen Parry

1Cancer Immunology and Immunotherapy Centre, Institute of Immunology and Immunotherapy, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT, UK.

2Department of Haematology, University Hospital Birmingham, Birmingham B15 2TH, UK.

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David Briggs

3National Health Service Blood and Transplant, Birmingham B15 2SG, UK.

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Ram Malladi

1Cancer Immunology and Immunotherapy Centre, Institute of Immunology and Immunotherapy, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT, UK.

2Department of Haematology, University Hospital Birmingham, Birmingham B15 2TH, UK.

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Benjamin E. Willcox

1Cancer Immunology and Immunotherapy Centre, Institute of Immunology and Immunotherapy, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT, UK.

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For correspondence: p.moss@bham.ac.uk b.willcox@bham.ac.uk

Paul Moss

1Cancer Immunology and Immunotherapy Centre, Institute of Immunology and Immunotherapy, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT, UK.

2Department of Haematology, University Hospital Birmingham, Birmingham B15 2TH, UK.

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For correspondence: p.moss@bham.ac.uk b.willcox@bham.ac.uk

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vol. 10 no. 481

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https://doi.org/10.1126/scisignal.aai8904

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Received December 23, 2015
Resubmitted August 26, 2016
Accepted May 11, 2017
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A disease-linked ULBP6 polymorphism inhibits NKG2D-mediated target cell killing by enhancing the stability of NKG2D ligand binding

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