A disease-linked ULBP6 polymorphism inhibits NKG2D-mediated target cell killing by enhancing the stability of NKG2D ligand binding

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  A disease-linked ULBP6 polymorphism inhibits NKG2D-mediated target cell killing by enhancing the stability of NKG2D ligand binding

  By Jianmin Zuo, Carrie R. Willcox, Fiyaz Mohammed, Martin Davey, Stuart Hunter, Kabir Khan, Ayman Antoun, Poonam Katakia, Joanne Croudace, Charlotte Inman, Helen Parry, David Briggs, Ram Malladi, Benjamin E. Willcox, Paul Moss

  Science Signaling30 May 2017

  A disease-associated variant of an activating ligand engages receptors so strongly that it impairs NK cell–mediated killing.

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  A disease-linked ULBP6 polymorphism inhibits NKG2D-mediated target cell killing by enhancing the stability of NKG2D ligand binding

  By Jianmin Zuo, Carrie R. Willcox, Fiyaz Mohammed, Martin Davey, Stuart Hunter, Kabir Khan, Ayman Antoun, Poonam Katakia, Joanne Croudace, Charlotte Inman, Helen Parry, David Briggs, Ram Malladi, Benjamin E. Willcox, Paul Moss

  Science Signaling30 May 2017

  A disease-associated variant of an activating ligand engages receptors so strongly that it impairs NK cell–mediated killing.

  • Supplementary Materials

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