Papers of note in Science 356 (6340)

Annalisa M. VanHook

doi:10.1126/scisignal.aan8309

This week’s articles highlight new research that identifies a microRNA decay pathway that promotes cell cycle progression; an interactive atlas of the subcellular localization of thousands of human proteins, which may help refine signaling networks; and a review of symbiotic plant-microbe interactions.

CELL BIOLOGY

Breaking down miRNAs

Elbarbary et al. identify an endonuclease that initiates decay of microRNAs that regulate the cell cycle.

PROTEOMICS

Mapping the proteome

Thul et al. generated the Cell Atlas, an image-based collection of 12,003 proteins and 13 organelles that reveals proteins that exhibit multiple localizations and single-cell variation (see also Horwitz and Johnson).

HOST-MICROBE INTERACTIONS

Taking a look at plant-microbe relationships

Martin et al. review the evolution of plant-symbiont interactions that modulate plant signaling pathways, development, and immunity.

Highlighted Articles

1. R. A. Elbarbary,
2. K. Miyoshi,
3. J. R. Myers,
4. P. Du,
5. J. M. Ashton,
6. B. Tian,
7. L. E. Maquat
, Tudor-SN–mediated endonucleolytic decay of human cell microRNAs promotes G₁/S phase transition. Science 356, 859–862 (2017).
OpenUrl Abstract/FREE Full Text
1. P. J. Thul,
2. L. Åkesson,
3. M. Wiking,
4. D. Mahdessian,
5. A. Geladaki,
6. H. Ait Blal,
7. T. Alm,
8. A. Asplund,
9. L. Björk,
10. L. M. Breckels,
11. A. Bäckström,
12. F. Danielsson,
13. L. Fagerberg,
14. J. Fall,
15. L. Gatto,
16. C. Gnann,
17. S. Hober,
18. M. Hjelmare,
19. F. Johansson,
20. S. Lee,
21. C. Lindskog,
22. J. Mulder,
23. C. M. Mulvey,
24. P. Nilsson,
25. P. Oksvold,
26. J. Rockberg,
27. R. Schutten,
28. J. M. Schwenk,
29. Å. Sivertsson,
30. E. Sjöstedt,
31. M. Skogs,
32. C. Stadler,
33. D. P. Sullivan,
34. H. Tegel,
35. C. Winsnes,
36. C. Zhang,
37. M. Zwahlen,
38. A. Mardinoglu,
39. F. Pontén,
40. K. von Feilitzen,
41. K. S. Lilley,
42. M. Uhlén,
43. E. Lundberg
, A subcellular map of the human proteome. Science 356, eaal3321 (2017).
OpenUrl Abstract/FREE Full Text
1. R. Horwitz,
2. G. T. Johnson
, Whole cell maps chart a course for 21st-century cell biology. Science 356, 806–807 (2017).
OpenUrl Abstract/FREE Full Text
1. F. M. Martin,
2. S. Uroz,
3. D. G. Barker
, Ancestral alliances: Plant mutualistic symbioses with fungi and bacteria. Science 356, eaad4501 (2017).
OpenUrl Abstract/FREE Full Text

View Abstract

[1] R. A. Elbarbary,
K. Miyoshi,
J. R. Myers,
P. Du,
J. M. Ashton,
B. Tian,
L. E. Maquat
, Tudor-SN–mediated endonucleolytic decay of human cell microRNAs promotes G₁/S phase transition. Science 356, 859–862 (2017).
OpenUrl Abstract/FREE Full Text

[2] R. A. Elbarbary,

[3] K. Miyoshi,

[4] J. R. Myers,

[5] P. Du,

[6] J. M. Ashton,

[7] B. Tian,

[8] L. E. Maquat

[9] P. J. Thul,
L. Åkesson,
M. Wiking,
D. Mahdessian,
A. Geladaki,
H. Ait Blal,
T. Alm,
A. Asplund,
L. Björk,
L. M. Breckels,
A. Bäckström,
F. Danielsson,
L. Fagerberg,
J. Fall,
L. Gatto,
C. Gnann,
S. Hober,
M. Hjelmare,
F. Johansson,
S. Lee,
C. Lindskog,
J. Mulder,
C. M. Mulvey,
P. Nilsson,
P. Oksvold,
J. Rockberg,
R. Schutten,
J. M. Schwenk,
Å. Sivertsson,
E. Sjöstedt,
M. Skogs,
C. Stadler,
D. P. Sullivan,
H. Tegel,
C. Winsnes,
C. Zhang,
M. Zwahlen,
A. Mardinoglu,
F. Pontén,
K. von Feilitzen,
K. S. Lilley,
M. Uhlén,
E. Lundberg
, A subcellular map of the human proteome. Science 356, eaal3321 (2017).
OpenUrl Abstract/FREE Full Text

[10] P. J. Thul,

[11] L. Åkesson,

[12] M. Wiking,

[13] D. Mahdessian,

[14] A. Geladaki,

[15] H. Ait Blal,

[16] T. Alm,

[17] A. Asplund,

[18] L. Björk,

[19] L. M. Breckels,

[20] A. Bäckström,

[21] F. Danielsson,

[22] L. Fagerberg,

[23] J. Fall,

[24] L. Gatto,

[25] C. Gnann,

[26] S. Hober,

[27] M. Hjelmare,

[28] F. Johansson,

[29] S. Lee,

[30] C. Lindskog,

[31] J. Mulder,

[32] C. M. Mulvey,

[33] P. Nilsson,

[34] P. Oksvold,

[35] J. Rockberg,

[36] R. Schutten,

[37] J. M. Schwenk,

[38] Å. Sivertsson,

[39] E. Sjöstedt,

[40] M. Skogs,

[41] C. Stadler,

[42] D. P. Sullivan,

[43] H. Tegel,

[44] C. Winsnes,

[45] C. Zhang,

[46] M. Zwahlen,

[47] A. Mardinoglu,

[48] F. Pontén,

[49] K. von Feilitzen,

[50] K. S. Lilley,

[51] M. Uhlén,

[52] E. Lundberg

[53] R. Horwitz,
G. T. Johnson
, Whole cell maps chart a course for 21st-century cell biology. Science 356, 806–807 (2017).
OpenUrl Abstract/FREE Full Text

[54] R. Horwitz,

[55] G. T. Johnson

[56] F. M. Martin,
S. Uroz,
D. G. Barker
, Ancestral alliances: Plant mutualistic symbioses with fungi and bacteria. Science 356, eaad4501 (2017).
OpenUrl Abstract/FREE Full Text

[57] F. M. Martin,

[58] S. Uroz,

[59] D. G. Barker

Papers of note in Science 356 (6340)

Highlighted Articles

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