06 June 2017
Vol 10, Issue 482

About The Cover

Cover image expansion

Online Cover This week features a Research Article that shows that cells lacking the transcription factor XBP1, which stimulates type I interferon (IFN) production as part of the unfolded protein response, are defective in controlling infection by the hepatitis C virus (HCV). Instead of being defective in IFN production, however, the XBP1-deficient infected cells failed to undergo apoptosis, thus facilitating increased viral replication. The image is an illustration of HCV. [Image: Dr_Microbe/istockphoto]