Contents
13 June 2017
Vol 10, Issue 483
Vol 10, Issue 483
Research Articles
- The lncRNA H19 mediates breast cancer cell plasticity during EMT and MET plasticity by differentially sponging miR-200b/c and let-7b
A long noncoding RNA selectively sponges microRNAs to enable epithelial-mesenchymal plasticity in metastasizing breast cancer cells.
- Ligand-activated Notch undergoes DTX4-mediated ubiquitylation and bilateral endocytosis before ADAM10 processing
Ubiquitylation of the receptor Notch1 triggers its endocytosis by ligand- and receptor-bearing cells before it undergoes processing by ADAM10.
- Regulation of the ubiquitylation and deubiquitylation of CREB-binding protein modulates histone acetylation and lung inflammation
The stability of the histone acetyltransferase CBP must be maintained to promote cytokine release and inflammation in the lung.
Review
- The lost language of the RNA World
RNA-derived signaling molecules in modern cells may represent evolutionary vestiges of a time when all cellular functions were performed by RNAs.
Editors' Choice
- Detecting and treating brain cancer
A systems biology approach identifies plasma biomarkers and potential therapeutic targets for patients with glioblastoma.
- Papers of note in Science 356 (6342)
This week’s articles explore the structural basis for nitrate sensing in bacteria, the importance of attenuating healing responses to reduce fibrosis and allergy, and the recruitment of chromatin silencing factors in X chromosome inactivation.
- Papers of note in Science Translational Medicine 9 (393)
This week’s articles describe a new combination therapy for BRCA1-mutant breast cancer and a new therapeutic target in patients with the ectopic calcification disease PXE.
- Papers of note in Nature 546 (7657)
This week’s articles highlight an unusual mechanism for switching off GPCR signaling; the structural basis of activation of the GLP-1 receptor; a critical role for the B cell receptor in some lymphoma cells; and how cancer cells exploit nutrient sensing and acquisition pathways.
About The Cover
Online Cover This week features a Research Article that shows that the long noncoding RNA H19 selectively sponges the microRNAs miR-200b/c and let-7b to enable epithelial-mesenchymal plasticity in metastasizing breast cancer cells in mice. Correlative support in human breast tumors suggests that targeting the H19 axis might prevent metastatic progression in patients. [Image: ilbusca, istockphoto]
