Editors' ChoiceCellular and Molecular Signaling

Papers of note in Nature 546 (7657)

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Science Signaling  13 Jun 2017:
Vol. 10, Issue 483, eaao0451
DOI: 10.1126/scisignal.aao0451

This week’s articles highlight an unusual mechanism for switching off GPCR signaling; the structural basis of activation of the GLP-1 receptor; a critical role for the B cell receptor in some lymphoma cells; and how cancer cells exploit nutrient sensing and acquisition pathways.


A GPCR off switch

Brockmann et al. identified an E3 ligase that switches G protein–coupled receptor signaling off by stimulating proteolysis of Gβγ heterodimers.

How the GLP-1 receptor gets activated

By solving the crystal structures of the human glucagon-like peptide-1 receptor in complex with two different negative allosteric regulators, Song et al. shed light on the conformational changes that are important for activation of the receptor.


Critical role for the BCR in lymphoma cell growth

Varano et al. report that B cell receptor–mediated inhibition of GSK-3β activity is important for the growth of MYC-driven lymphoma cells.

Nutrient acquisition by cancer cells

Palm and Thompson review the mechanisms by which mammalian cells sense and acquire nutrients and how cancer cells can exploit these processes.

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