Contents
20 June 2017
Vol 10, Issue 484
Vol 10, Issue 484
Research Articles
- Ligand- and voltage-gated Ca2+ channels differentially regulate the mode of vesicular neuropeptide release in mammalian sensory neurons
Neurotransmission of sensory input is determined by the type of calcium channel that is activated.
- The glycosylation pathway is required for the secretion of Slit and for the maintenance of the Slit receptor Robo on axons
Glycosylation of the guidance cue Slit is required for proper positioning and maintenance of axon tracts in the fruit fly.
- Genetic evidence that β-arrestins are dispensable for the initiation of β2-adrenergic receptor signaling to ERK
Ligand activation of β2-adrenergic receptors induces the phosphorylation of the kinase ERK in a β-arrestin–independent manner.
Editors' Choice
- Macrophages don’t take more than they can eat
Innate immune signaling feeds forward to control the rate at which macrophages phagocytose bacteria.
- Dazed and confused from infection
TNF-α produced by circulating CX3CR1high monocytes causes the problems that infected individuals have with learning and remembering.
- Papers of note in Science 356 (6343)
This week’s articles describe a mechanism by which starvation primes a cellular nutrient-sensing system for activation upon refeeding; microRNAs that control pain sensitivity; and the lasting effects of early life stress on the likelihood of developing depression.
- Papers of note in Science Translational Medicine 9 (394)
This week’s articles describe how broccoli can combat type 2 diabetes, how monocytes contribute to the failure of organ transplant grafts, and how to more durably treat RET- or KRAS-driven lung cancer.
- Papers of note in Nature 546 (7658)
This week’s articles highlight a compound that may be useful for treating cryptosporidiosis and a kinase complex that links cell division to cellular metabolism.
About The Cover
Online Cover This week features a Research Article that describes how two calcium ion channels differentially regulate the mode of neuropeptide release from sensory neurons, thereby altering the intensity and duration of neurotransmission, such as that which mediates the sensation of pain. The image is an artist's rendition of synaptic transmission. [Image: Cosmin4000/istockphoto]