Research ArticleGPCR SIGNALING
Genetic evidence that β-arrestins are dispensable for the initiation of β2-adrenergic receptor signaling to ERK
- View ORCID ProfileMorgan O’Hayre1,
- Kelsie Eichel2,*,
- Silvia Avino1,3,*,
- View ORCID ProfileXuefeng Zhao1,4,5,
- Dana J. Steffen4,
- View ORCID ProfileXiaodong Feng1,4,
- Kouki Kawakami6,
- Junken Aoki6,7,
- Karen Messer4,
- Roger Sunahara4,
- Asuka Inoue6,8,
- View ORCID ProfileMark von Zastrow2,9, and
- View ORCID ProfileJ. Silvio Gutkind1,4,†
- 1Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20852, USA.
- 2Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94158, USA.
- 3Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via Pietro Bucci, 87036 Rende (CS), Italy.
- 4Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
- 5State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
- 6Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba-ku, Sendai, Miyagi 980-8578, Japan.
- 7Japan Agency for Medical Research and Development, Core Research for Evolutional Science and Technology, Chiyoda-ku, Tokyo 100-0004, Japan.
- 8Japan Science and Technology Agency, Precursory Research for Embryonic Science and Technology, Kawaguchi, Saitama 332-0012, Japan.
- 9Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.
- ↵†Corresponding author. Email: sgutkind{at}ucsd.edu
↵* These authors contributed equally to this work.
See allHide authors and affiliations
Science Signaling 20 Jun 2017:
Vol. 10, Issue 484, eaal3395
DOI: 10.1126/scisignal.aal3395
Vol. 10, Issue 484, eaal3395
DOI: 10.1126/scisignal.aal3395
Morgan O’Hayre
1Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20852, USA.
Kelsie Eichel
2Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94158, USA.
Silvia Avino
1Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20852, USA.
3Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via Pietro Bucci, 87036 Rende (CS), Italy.
Xuefeng Zhao
1Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20852, USA.
4Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
5State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Dana J. Steffen
4Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
Xiaodong Feng
1Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20852, USA.
4Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
Kouki Kawakami
6Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba-ku, Sendai, Miyagi 980-8578, Japan.
Junken Aoki
6Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba-ku, Sendai, Miyagi 980-8578, Japan.
7Japan Agency for Medical Research and Development, Core Research for Evolutional Science and Technology, Chiyoda-ku, Tokyo 100-0004, Japan.
Karen Messer
4Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
Roger Sunahara
4Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
Asuka Inoue
6Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba-ku, Sendai, Miyagi 980-8578, Japan.
8Japan Science and Technology Agency, Precursory Research for Embryonic Science and Technology, Kawaguchi, Saitama 332-0012, Japan.
Mark von Zastrow
2Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94158, USA.
9Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.
J. Silvio Gutkind
1Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20852, USA.
4Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
