Papers of note in Science 356 (6343)

Annalisa M. VanHook

doi:10.1126/scisignal.aao1166

This week’s articles describe a mechanism by which starvation primes a cellular nutrient-sensing system for activation upon refeeding; microRNAs that control pain sensitivity; and the lasting effects of early life stress on the likelihood of developing depression.

CELLULAR METABOLISM

Preparing for the feast during the fast

Di Malta et al. report on a transcriptional regulatory mechanism that enables cellular adaptation to nutrient availability and supports cancer metabolism.

NEUROSCIENCE

MicroRNAs in functional and dysfunctional pain

Peng et al. describe a cluster of microRNAs that regulate both normal pain sensitivity and the pathological responses of chronic pain (see also Cassels and Barde).

Early life stress in depression susceptibility

Peña et al. identify an early window of stress susceptibility that defines a mouse’s response to stress in adulthood.

Highlighted Articles

1. C. Di Malta,
2. D. Siciliano,
3. A. Calcagni,
4. J. Monfregola,
5. S. Punzi,
6. N. Pastore,
7. A. N. Eastes,
8. O. Davis,
9. R. De Cegli,
10. A. Zampelli,
11. L. G. Di Giovannantonio,
12. E. Nusco,
13. N. Platt,
14. A. Guida,
15. M. H. Ogmundsdottir,
16. L. Lanfrancone,
17. R. M. Perera,
18. R. Zoncu,
19. P. G. Pelicci,
20. C. Settembre,
21. A. Ballabio
, Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth. Science 356, 1188–1192 (2017).
OpenUrl Abstract/FREE Full Text
1. C. Peng,
2. L. Li,
3. M.-D. Zhang,
4. C. B. Gonzales,
5. M. Parisien,
6. I. Belfer,
7. D. Usoskin,
8. H. Abdo,
9. A. Furlan,
10. M. Häring,
11. F. Lallemend,
12. T. Harkany,
13. L. Diatchenko,
14. T. Hökfelt,
15. J. Hjerling-Leffler,
16. P. Ernfors
, miR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes. Science 356, 1168–1171 (2017).
OpenUrl Abstract/FREE Full Text
1. L. Cassels,
2. Y.-A. Barde
, Scaling pain threshold with microRNAs. Science 356, 1124–1125 (2017).
OpenUrl Abstract/FREE Full Text
1. C. J. Peña,
2. H. G. Kronman,
3. D. M. Walker,
4. H. M. Cates,
5. R. C. Bagot,
6. I. Purushothaman,
7. O. Issler,
8. Y.-H. E. Loh,
9. T. Leong,
10. D. D. Kiraly,
11. E. Goodman,
12. R. L. Neve,
13. L. Shen,
14. E. J. Nestler
, Early life stress confers lifelong stress susceptibility in mice via ventral tegmental area OTX2. Science 356, 1185–1188 (2017).
OpenUrl Abstract/FREE Full Text

View Abstract

[1] C. Di Malta,
D. Siciliano,
A. Calcagni,
J. Monfregola,
S. Punzi,
N. Pastore,
A. N. Eastes,
O. Davis,
R. De Cegli,
A. Zampelli,
L. G. Di Giovannantonio,
E. Nusco,
N. Platt,
A. Guida,
M. H. Ogmundsdottir,
L. Lanfrancone,
R. M. Perera,
R. Zoncu,
P. G. Pelicci,
C. Settembre,
A. Ballabio
, Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth. Science 356, 1188–1192 (2017).
OpenUrl Abstract/FREE Full Text

[2] C. Di Malta,

[3] D. Siciliano,

[4] A. Calcagni,

[5] J. Monfregola,

[6] S. Punzi,

[7] N. Pastore,

[8] A. N. Eastes,

[9] O. Davis,

[10] R. De Cegli,

[11] A. Zampelli,

[12] L. G. Di Giovannantonio,

[13] E. Nusco,

[14] N. Platt,

[15] A. Guida,

[16] M. H. Ogmundsdottir,

[17] L. Lanfrancone,

[18] R. M. Perera,

[19] R. Zoncu,

[20] P. G. Pelicci,

[21] C. Settembre,

[22] A. Ballabio

[23] C. Peng,
L. Li,
M.-D. Zhang,
C. B. Gonzales,
M. Parisien,
I. Belfer,
D. Usoskin,
H. Abdo,
A. Furlan,
M. Häring,
F. Lallemend,
T. Harkany,
L. Diatchenko,
T. Hökfelt,
J. Hjerling-Leffler,
P. Ernfors
, miR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes. Science 356, 1168–1171 (2017).
OpenUrl Abstract/FREE Full Text

[24] C. Peng,

[25] L. Li,

[26] M.-D. Zhang,

[27] C. B. Gonzales,

[28] M. Parisien,

[29] I. Belfer,

[30] D. Usoskin,

[31] H. Abdo,

[32] A. Furlan,

[33] M. Häring,

[34] F. Lallemend,

[35] T. Harkany,

[36] L. Diatchenko,

[37] T. Hökfelt,

[38] J. Hjerling-Leffler,

[39] P. Ernfors

[40] L. Cassels,
Y.-A. Barde
, Scaling pain threshold with microRNAs. Science 356, 1124–1125 (2017).
OpenUrl Abstract/FREE Full Text

[41] L. Cassels,

[42] Y.-A. Barde

[43] C. J. Peña,
H. G. Kronman,
D. M. Walker,
H. M. Cates,
R. C. Bagot,
I. Purushothaman,
O. Issler,
Y.-H. E. Loh,
T. Leong,
D. D. Kiraly,
E. Goodman,
R. L. Neve,
L. Shen,
E. J. Nestler
, Early life stress confers lifelong stress susceptibility in mice via ventral tegmental area OTX2. Science 356, 1185–1188 (2017).
OpenUrl Abstract/FREE Full Text

[44] C. J. Peña,

[45] H. G. Kronman,

[46] D. M. Walker,

[47] H. M. Cates,

[48] R. C. Bagot,

[49] I. Purushothaman,

[50] O. Issler,

[51] Y.-H. E. Loh,

[52] T. Leong,

[53] D. D. Kiraly,

[54] E. Goodman,

[55] R. L. Neve,

[56] L. Shen,

[57] E. J. Nestler

Papers of note in Science 356 (6343)

Highlighted Articles

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