Editors' ChoiceCellular and Molecular Signaling

Papers of note in Nature 546 (7658)

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Science Signaling  20 Jun 2017:
Vol. 10, Issue 484, eaao1168
DOI: 10.1126/scisignal.aao1168

This week’s articles highlight a compound that may be useful for treating cryptosporidiosis and a kinase complex that links cell division to cellular metabolism.


Targeting a protozoan parasite

Manjunatha et al. report that a pharmacological inhibitor of the Cryptosporidium lipid kinase PI(4)K promotes parasite clearance and improves symptoms in animal models of cryptosporidiosis.


Linking cell proliferation to cellular metabolism

Wang et al. found that a kinase complex that promotes cell division and is highly active in some cancers stimulates changes in cellular metabolism that promote cancer cell survival (see also Krall and Christofk).

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