Papers of note in Nature 546 (7658)

Annalisa M. VanHook

doi:10.1126/scisignal.aao1168

This week’s articles highlight a compound that may be useful for treating cryptosporidiosis and a kinase complex that links cell division to cellular metabolism.

PARASITOLOGY

Targeting a protozoan parasite

Manjunatha et al. report that a pharmacological inhibitor of the Cryptosporidium lipid kinase PI(4)K promotes parasite clearance and improves symptoms in animal models of cryptosporidiosis.

CANCER

Linking cell proliferation to cellular metabolism

Wang et al. found that a kinase complex that promotes cell division and is highly active in some cancers stimulates changes in cellular metabolism that promote cancer cell survival (see also Krall and Christofk).

Highlighted Articles

1. U. H. Manjunatha,
2. S. Vinayak,
3. J. A. Zambriski,
4. A. T. Chao,
5. T. Sy,
6. C. G. Noble,
7. G. M. C. Bonamy,
8. R. R. Kondreddi,
9. B. Zou,
10. P. Gedeck,
11. C. F. Brooks,
12. G. T. Herbert,
13. A. Sateriale,
14. J. Tandel,
15. S. Noh,
16. S. B. Lakshminarayana,
17. S. H. Lim,
18. L. B. Goodman,
19. C. Bodenreider,
20. G. Feng,
21. L. Zhang,
22. F. Blasco,
23. J. Wagner,
24. F. J. Leong,
25. B. Striepen,
26. T. T. Diagana
, A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis. Nature 546, 376–380 (2017).
OpenUrl
1. H. Wang,
2. B. N. Nicolay,
3. J. M. Chick,
4. X. Gao,
5. Y. Geng,
6. H. Ren,
7. H. Gao,
8. G. Yang,
9. J. A. Williams,
10. J. M. Suski,
11. M. A. Keibler,
12. E. Sicinska,
13. U. Gerdemann,
14. W. N. Haining,
15. T. M. Roberts,
16. K. Polyak,
17. S. P. Gygi,
18. N. J. Dyson,
19. P. Sicinski
, The metabolic function of cyclin D3–CDK6 kinase in cancer cell survival. Nature 546, 426–430 (2017).
OpenUrl
1. A. S. Krall,
2. H. R. Christofk
, Division enzyme regulates metabolism. Nature 546, 357–358 (2017).
OpenUrl

View Abstract

This week’s articles highlight a compound that may be useful for treating cryptosporidiosis and a kinase complex that links cell division to cellular metabolism.

[1] U. H. Manjunatha,
S. Vinayak,
J. A. Zambriski,
A. T. Chao,
T. Sy,
C. G. Noble,
G. M. C. Bonamy,
R. R. Kondreddi,
B. Zou,
P. Gedeck,
C. F. Brooks,
G. T. Herbert,
A. Sateriale,
J. Tandel,
S. Noh,
S. B. Lakshminarayana,
S. H. Lim,
L. B. Goodman,
C. Bodenreider,
G. Feng,
L. Zhang,
F. Blasco,
J. Wagner,
F. J. Leong,
B. Striepen,
T. T. Diagana
, A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis. Nature 546, 376–380 (2017).
OpenUrl

[2] U. H. Manjunatha,

[3] S. Vinayak,

[4] J. A. Zambriski,

[5] A. T. Chao,

[6] T. Sy,

[7] C. G. Noble,

[8] G. M. C. Bonamy,

[9] R. R. Kondreddi,

[10] B. Zou,

[11] P. Gedeck,

[12] C. F. Brooks,

[13] G. T. Herbert,

[14] A. Sateriale,

[15] J. Tandel,

[16] S. Noh,

[17] S. B. Lakshminarayana,

[18] S. H. Lim,

[19] L. B. Goodman,

[20] C. Bodenreider,

[21] G. Feng,

[22] L. Zhang,

[23] F. Blasco,

[24] J. Wagner,

[25] F. J. Leong,

[26] B. Striepen,

[27] T. T. Diagana

[28] H. Wang,
B. N. Nicolay,
J. M. Chick,
X. Gao,
Y. Geng,
H. Ren,
H. Gao,
G. Yang,
J. A. Williams,
J. M. Suski,
M. A. Keibler,
E. Sicinska,
U. Gerdemann,
W. N. Haining,
T. M. Roberts,
K. Polyak,
S. P. Gygi,
N. J. Dyson,
P. Sicinski
, The metabolic function of cyclin D3–CDK6 kinase in cancer cell survival. Nature 546, 426–430 (2017).
OpenUrl

[29] H. Wang,

[30] B. N. Nicolay,

[31] J. M. Chick,

[32] X. Gao,

[33] Y. Geng,

[34] H. Ren,

[35] H. Gao,

[36] G. Yang,

[37] J. A. Williams,

[38] J. M. Suski,

[39] M. A. Keibler,

[40] E. Sicinska,

[41] U. Gerdemann,

[42] W. N. Haining,

[43] T. M. Roberts,

[44] K. Polyak,

[45] S. P. Gygi,

[46] N. J. Dyson,

[47] P. Sicinski

[48] A. S. Krall,
H. R. Christofk
, Division enzyme regulates metabolism. Nature 546, 357–358 (2017).
OpenUrl

[49] A. S. Krall,

[50] H. R. Christofk

Papers of note in Nature 546 (7658)

Highlighted Articles

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