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Papers of note in Science Translational Medicine 9 (394)

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Science Signaling  20 Jun 2017:
Vol. 10, Issue 484, eaao1186
DOI: 10.1126/scisignal.aao1186

This week’s articles describe how broccoli can combat type 2 diabetes, how monocytes contribute to the failure of organ transplant grafts, and how to more durably treat RET- or KRAS-driven lung cancer.


Nonclassical monocytes prompt primary graft dysfunction

Zheng et al. found that inhibiting chemokine secretion from a population of monocytes may improve graft success in patients receiving organ transplants.


Another reason to eat your broccoli

Axelsson et al. showed that sulforaphane, a natural compound found in broccoli and other vegetables, might improve the control of glucose metabolism in patients with type 2 diabetes by activating the NRF2 antioxidant pathway.


RET-ting out lung tumors

Plenker et al. found that drugs that bind and lock the kinase RET in an inactive state, combined with drugs that block drug-induced MAPK-mediated resistance, may be successful in treating patients with RET-rearranged lung cancer.

An antisensible approach to targeting KRAS

Ross et al. developed a modified antisense oligonucleotide-based therapy that inhibited KRAS signaling in lung tumors without activating MAPK feedback–mediated drug resistance.

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