Contents
04 July 2017
Vol 10, Issue 486
Vol 10, Issue 486
Perspective
- A perspective on AKT 25-plus years after its discovery
A look at AKT shows that there is still much more to learn about this central signaling kinase.
Research Articles
- Voltage-dependent Ca2+ entry into smooth muscle during contraction promotes endothelium-mediated feedback vasodilation in arterioles
Ca2+ entry into vascular smooth muscle activates Ca2+ signaling in the endothelium to protect tissue blood flow.
- TGF-β promotes PI3K-AKT signaling and prostate cancer cell migration through the TRAF6-mediated ubiquitylation of p85α
The TGF-β signaling pathways are not as insulated from each other as was once thought.
Editors' Choice
- A therapy for FXS?
The antidiabetic drug metformin might be repurposed to treat patients with fragile X syndrome.
- Papers of note in Science Immunology 2 (12)
This month’s articles show how Plasmodium by-products cause bone loss and how citrullination of an NF-κB subunit enhances inflammatory responses.
- Papers of note in Science Translational Medicine 9 (396)
This week’s articles describe ways to potentially treat lymphoma and fatty liver–associated fibrosis.
- Papers of note in Science 356 (6345)
This week’s articles address the release of volatile organic compounds from plant cells, a gene regulatory network that ensures proper neural patterning despite variability in morphogen gradients, and a role for adenosine signaling in the plasticity of an auditory circuit.
- Papers of note in Nature 546 (7660)
This week’s articles highlight a mechanism by which melanoma cells prepare the metastatic niche, intestinal defense against rotavirus, and immune tolerance in the human fetus.
About The Cover
Online Cover This week features a Research Article that shows Ca2+ entry into vascular smooth muscle during vasoconstriction activates Ca2+ signaling in the endothelium and vasodilation to protect tissue blood flow. The image shows a pressurized arteriole stained for a voltage-gated Ca2+ channel (yellow) and elastin (white). Vascular smooth muscle cells have vertically aligned nuclei (blue), and endothelial cells have horizontally aligned nuclei (blue). [Image: Pooneh Bagher/University of Oxford, UK]