Papers of note in Nature 546 (7660)

Annalisa M. VanHook

doi:10.1126/scisignal.aao2378

This week’s articles highlight a mechanism by which melanoma cells prepare the metastatic niche, intestinal defense against rotavirus, and immune tolerance in the human fetus.

CANCER

Melanomas prep the premetastatic niche

Olmeda et al. found that melanoma cells secrete a growth factor that stimulates lymphangiogenesis in distant tissues, thus preparing the premetastatic niche (see also Hoshino and Lyden).

IMMUOLOGY

How intestinal cells battle rotavirus

Zhu et al. identified the subset of inflammasomes that mediate intestinal defense against rotavirus infection (see also Saavedra and Lamkanfi).

Tolerance in the fetal immune system

McGovern et al. report that a subset of dendritic cells in the human fetus promotes immune tolerance in part by degrading an amino acid that is required for the production of the proinflammatory cytokine TNF-α.

Highlighted Articles

1. D. Olmeda,
2. D. Cerezo-Wallis,
3. E. Riveiro-Falkenbach,
4. P. C. Pennacchi,
5. M. Contreras-Alcalde,
6. N. Ibarz,
7. M. Cifdaloz,
8. X. Catena,
9. T. G. Calvo,
10. E. Cañón,
11. D. Alonso-Curbelo,
12. J. Suarez,
13. L. Osterloh,
14. O. Graña,
15. F. Mulero,
16. D. Megías,
17. M. Cañamero,
18. J. L. Martínez-Torrecuadrada,
19. C. Mondal,
20. J. Di Martino,
21. D. Lora,
22. I. Martinez-Corral,
23. J. J. Bravo-Cordero,
24. J. Muñoz,
25. S. Puig,
26. P. Ortiz-Romero,
27. J. L. Rodriguez-Peralto,
28. S. Ortega,
29. M. S. Soengas
, Whole-body imaging of lymphovascular niches identifies pre-metastatic roles of midkine. Nature 546, 676–680 (2017).
OpenUrl
1. A. Hoshino,
2. D. Lyden
, Lymphatic detours for cancer. Nature 546, 609–610 (2017).
OpenUrl
1. S. Zhu,
2. S. Ding,
3. P. Wang,
4. Z. Wei,
5. W. Pan,
6. N. W. Palm,
7. Y. Yang,
8. H. Yu,
9. H.-B. Li,
10. G. Wang,
11. X. Lei,
12. M. R. de Zoete,
13. J. Zhao,
14. Y. Zheng,
15. H. Chen,
16. Y. Zhao,
17. K. A. Jurado,
18. N. Feng,
19. L. Shan,
20. Y. Kluger,
21. J. Lu,
22. C. Abraham,
23. E. Fikrig,
24. H. B. Greenberg,
25. R. A. Flavell
, Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells. Nature 546, 667–670 (2017).
OpenUrl
1. P. H. V. Saavedra,
2. M. Lamkanfi
, Gut sensor halts viral attack. Nature 546, 606–608 (2017).
OpenUrl
1. N. McGovern,
2. A. Shin,
3. G. Low,
4. D. Low,
5. K. Duan,
6. L. J. Yao,
7. R. Msallam,
8. I. Low,
9. N. B. Shadan,
10. H. R. Sumatoh,
11. E. Soon,
12. J. Lum,
13. E. Mok,
14. S. Hubert,
15. P. See,
16. E. H. Kunxiang,
17. Y. H. Lee,
18. B. Janela,
19. M. Choolani,
20. C. N. Z. Mattar,
21. Y. Fan,
22. T. K. H. Lim,
23. D. K. H. Chan,
24. K.-K. Tan,
25. J. K. C. Tam,
26. C. Schuster,
27. A. Elbe-Bürger,
28. X. -n Wang,
29. V. Bigley,
30. M. Collin,
31. M. Haniffa,
32. A. Schlitzer,
33. M. Poidinger,
34. S. Albani,
35. A. Larbi,
36. E. W. Newell,
37. J. K. Y. Chan,
38. F. Ginhoux
, Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2. Nature 546, 662–666 (2017).
OpenUrl

View Abstract

This week’s articles highlight a mechanism by which melanoma cells prepare the metastatic niche, intestinal defense against rotavirus, and immune tolerance in the human fetus.

[1] D. Olmeda,
D. Cerezo-Wallis,
E. Riveiro-Falkenbach,
P. C. Pennacchi,
M. Contreras-Alcalde,
N. Ibarz,
M. Cifdaloz,
X. Catena,
T. G. Calvo,
E. Cañón,
D. Alonso-Curbelo,
J. Suarez,
L. Osterloh,
O. Graña,
F. Mulero,
D. Megías,
M. Cañamero,
J. L. Martínez-Torrecuadrada,
C. Mondal,
J. Di Martino,
D. Lora,
I. Martinez-Corral,
J. J. Bravo-Cordero,
J. Muñoz,
S. Puig,
P. Ortiz-Romero,
J. L. Rodriguez-Peralto,
S. Ortega,
M. S. Soengas
, Whole-body imaging of lymphovascular niches identifies pre-metastatic roles of midkine. Nature 546, 676–680 (2017).
OpenUrl

[2] D. Olmeda,

[3] D. Cerezo-Wallis,

[4] E. Riveiro-Falkenbach,

[5] P. C. Pennacchi,

[6] M. Contreras-Alcalde,

[7] N. Ibarz,

[8] M. Cifdaloz,

[9] X. Catena,

[10] T. G. Calvo,

[11] E. Cañón,

[12] D. Alonso-Curbelo,

[13] J. Suarez,

[14] L. Osterloh,

[15] O. Graña,

[16] F. Mulero,

[17] D. Megías,

[18] M. Cañamero,

[19] J. L. Martínez-Torrecuadrada,

[20] C. Mondal,

[21] J. Di Martino,

[22] D. Lora,

[23] I. Martinez-Corral,

[24] J. J. Bravo-Cordero,

[25] J. Muñoz,

[26] S. Puig,

[27] P. Ortiz-Romero,

[28] J. L. Rodriguez-Peralto,

[29] S. Ortega,

[30] M. S. Soengas

[31] A. Hoshino,
D. Lyden
, Lymphatic detours for cancer. Nature 546, 609–610 (2017).
OpenUrl

[32] A. Hoshino,

[33] D. Lyden

[34] S. Zhu,
S. Ding,
P. Wang,
Z. Wei,
W. Pan,
N. W. Palm,
Y. Yang,
H. Yu,
H.-B. Li,
G. Wang,
X. Lei,
M. R. de Zoete,
J. Zhao,
Y. Zheng,
H. Chen,
Y. Zhao,
K. A. Jurado,
N. Feng,
L. Shan,
Y. Kluger,
J. Lu,
C. Abraham,
E. Fikrig,
H. B. Greenberg,
R. A. Flavell
, Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells. Nature 546, 667–670 (2017).
OpenUrl

[35] S. Zhu,

[36] S. Ding,

[37] P. Wang,

[38] Z. Wei,

[39] W. Pan,

[40] N. W. Palm,

[41] Y. Yang,

[42] H. Yu,

[43] H.-B. Li,

[44] G. Wang,

[45] X. Lei,

[46] M. R. de Zoete,

[47] J. Zhao,

[48] Y. Zheng,

[49] H. Chen,

[50] Y. Zhao,

[51] K. A. Jurado,

[52] N. Feng,

[53] L. Shan,

[54] Y. Kluger,

[55] J. Lu,

[56] C. Abraham,

[57] E. Fikrig,

[58] H. B. Greenberg,

[59] R. A. Flavell

[60] P. H. V. Saavedra,
M. Lamkanfi
, Gut sensor halts viral attack. Nature 546, 606–608 (2017).
OpenUrl

[61] P. H. V. Saavedra,

[62] M. Lamkanfi

[63] N. McGovern,
A. Shin,
G. Low,
D. Low,
K. Duan,
L. J. Yao,
R. Msallam,
I. Low,
N. B. Shadan,
H. R. Sumatoh,
E. Soon,
J. Lum,
E. Mok,
S. Hubert,
P. See,
E. H. Kunxiang,
Y. H. Lee,
B. Janela,
M. Choolani,
C. N. Z. Mattar,
Y. Fan,
T. K. H. Lim,
D. K. H. Chan,
K.-K. Tan,
J. K. C. Tam,
C. Schuster,
A. Elbe-Bürger,
X. -n Wang,
V. Bigley,
M. Collin,
M. Haniffa,
A. Schlitzer,
M. Poidinger,
S. Albani,
A. Larbi,
E. W. Newell,
J. K. Y. Chan,
F. Ginhoux
, Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2. Nature 546, 662–666 (2017).
OpenUrl

[64] N. McGovern,

[65] A. Shin,

[66] G. Low,

[67] D. Low,

[68] K. Duan,

[69] L. J. Yao,

[70] R. Msallam,

[71] I. Low,

[72] N. B. Shadan,

[73] H. R. Sumatoh,

[74] E. Soon,

[75] J. Lum,

[76] E. Mok,

[77] S. Hubert,

[78] P. See,

[79] E. H. Kunxiang,

[80] Y. H. Lee,

[81] B. Janela,

[82] M. Choolani,

[83] C. N. Z. Mattar,

[84] Y. Fan,

[85] T. K. H. Lim,

[86] D. K. H. Chan,

[87] K.-K. Tan,

[88] J. K. C. Tam,

[89] C. Schuster,

[90] A. Elbe-Bürger,

[91] X. -n Wang,

[92] V. Bigley,

[93] M. Collin,

[94] M. Haniffa,

[95] A. Schlitzer,

[96] M. Poidinger,

[97] S. Albani,

[98] A. Larbi,

[99] E. W. Newell,

[100] J. K. Y. Chan,

[101] F. Ginhoux

Papers of note in Nature 546 (7660)

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