Papers of note in Science Immunology 2 (12)

John F. Foley

doi:10.1126/scisignal.aao2382

This month’s articles show how Plasmodium by-products cause bone loss and how citrullination of an NF-κB subunit enhances inflammatory responses.

INFECTIOUS DISEASE

Plasmodium leftovers cause bone loss

Lee et al. show that Plasmodium by-products induce an inflammatory response in the bone marrow that leads to bone loss in patients that have recovered from malaria.

AUTOIMMUNITY

PADs inflame arthritis

Sun et al. show that the NF-κB subunit p65 is citrullinated, enhancing its entry into the nucleus, where it induces the expression of genes encoding proinflammatory cytokines.

Highlighted Articles

1. M. S. J. Lee,
2. K. Maruyama,
3. Y. Fujita,
4. A. Konishi,
5. P. M. Lelliott,
6. S. Itagaki,
7. T. Horii,
8. J.-w. Lin,
9. S. M. Khan,
10. E. Kuroda,
11. S. Akira,
12. K. J. Ishii,
13. C. Coban
, Plasmodium products persist in the bone marrow and promote chronic bone loss. Sci. Immunol. 2, eaam8093 (2017).
OpenUrl Abstract/FREE Full Text
1. B. Sun,
2. N. Dwivedi,
3. T. J. Bechtel,
4. J. L. Paulsen,
5. A. Muth,
6. M. Bawadekar,
7. G. Li,
8. P. R. Thompson,
9. M. A. Shelef,
10. C. A. Schiffer,
11. E. Weerapana,
12. I.-C. Ho
, Citrullination of NF-κB p65 promotes its nuclear localization and TLR-induced expression of IL-1β and TNFα. Sci. Immunol. 2, eaal3062 (2017).
OpenUrl Abstract/FREE Full Text

View Abstract

This month’s articles show how Plasmodium by-products cause bone loss and how citrullination of an NF-κB subunit enhances inflammatory responses.

[1] M. S. J. Lee,
K. Maruyama,
Y. Fujita,
A. Konishi,
P. M. Lelliott,
S. Itagaki,
T. Horii,
J.-w. Lin,
S. M. Khan,
E. Kuroda,
S. Akira,
K. J. Ishii,
C. Coban
, Plasmodium products persist in the bone marrow and promote chronic bone loss. Sci. Immunol. 2, eaam8093 (2017).
OpenUrl Abstract/FREE Full Text

[2] M. S. J. Lee,

[3] K. Maruyama,

[4] Y. Fujita,

[5] A. Konishi,

[6] P. M. Lelliott,

[7] S. Itagaki,

[8] T. Horii,

[9] J.-w. Lin,

[10] S. M. Khan,

[11] E. Kuroda,

[12] S. Akira,

[13] K. J. Ishii,

[14] C. Coban

[15] B. Sun,
N. Dwivedi,
T. J. Bechtel,
J. L. Paulsen,
A. Muth,
M. Bawadekar,
G. Li,
P. R. Thompson,
M. A. Shelef,
C. A. Schiffer,
E. Weerapana,
I.-C. Ho
, Citrullination of NF-κB p65 promotes its nuclear localization and TLR-induced expression of IL-1β and TNFα. Sci. Immunol. 2, eaal3062 (2017).
OpenUrl Abstract/FREE Full Text

[16] B. Sun,

[17] N. Dwivedi,

[18] T. J. Bechtel,

[19] J. L. Paulsen,

[20] A. Muth,

[21] M. Bawadekar,

[22] G. Li,

[23] P. R. Thompson,

[24] M. A. Shelef,

[25] C. A. Schiffer,

[26] E. Weerapana,

[27] I.-C. Ho

Papers of note in Science Immunology 2 (12)

Highlighted Articles

Sci. Signal.

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