Papers of note in Nature 547 (7661)

Annalisa M. VanHook

doi:10.1126/scisignal.aao3019

This week’s articles highlight progress in predicting T cell receptor specificity; an evolutionarily ancient form of antiviral defense; a mechanism of chemotherapy-induced cell death; metabolic rewiring in cancer cells; and structural insights into activation of a GPCR and of a mechanosensitive ion channel.

IMMUNOLOGY

Predicting TCR specificity

Dash et al. and Glanville et al. developed methods for using the sequence of a T cell receptor to predict its antigen specificity (see also Reddy).

Ancient antiviral defense

Aguado et al. showed that RNase III nucleases from plants, invertebrates, and vertebrates suppress replication of RNA viruses by binding to viral RNA and inhibiting the viral RNA polymerase.

CANCER

Chemotherapy-induced pyroptosis

Wang et al. found that chemotherapy drugs that activate caspase-3 trigger pyroptosis through a mechanism that depends on gasdermin E.

Metabolic rewiring through mTOR

Zabala-Letona et al. showed that mTORC1 promotes tumorigenesis by stimulating the synthesis of polyamines.

STRUCTURAL BIOLOGY

GPCR activation

Gregorio et al. showed how ligand binding to the β₂-adrenergic receptor allosterically affects nucleotide binding to the downstream G protein.

Coupling force to channel opening

Jin et al. used cryo–electron microscopy to investigate how force causes the mechanosensitive channel NOMPC to open.

Highlighted Articles

1. P. Dash,
2. A. J. Fiore-Gartland,
3. T. Hertz,
4. G. C. Wang,
5. S. Sharma,
6. A. Souquette,
7. J. C. Crawford,
8. E. B. Clemens,
9. T. H. O. Nguyen,
10. K. Kedzierska,
11. N. L. La Gruta,
12. P. Bradley,
13. P. G. Thomas
, Quantifiable predictive features define epitope-specific T cell receptor repertoires. Nature 547, 89–93 (2017).
OpenUrl
1. J. Glanville,
2. H. Huang,
3. A. Nau,
4. O. Hatton,
5. L. E. Wagar,
6. F. Rubelt,
7. X. Ji,
8. A. Han,
9. S. M. Krams,
10. C. Pettus,
11. N. Haas,
12. C. S. Lindestam Arlehamn,
13. A. Sette,
14. S. D. Boyd,
15. T. J. Scriba,
16. O. M. Martinez,
17. M. M. Davis
, Identifying specificity groups in the T cell receptor repertoire. Nature 547, 94–98 (2017).
OpenUrl
1. S. T. Reddy
, The patterns of T-cell target recognition. Nature 547, 36–38 (2017).
OpenUrl
1. L. C. Aguado,
2. S. Schmid,
3. J. May,
4. L. R. Sabin,
5. M. Panis,
6. D. Blanco-Melo,
7. J. V. Shim,
8. D. Sachs,
9. S. Cherry,
10. A. E. Simon,
11. J.-P. Levraud,
12. B. R. tenOever
, RNase III nucleases from diverse kingdoms serve as antiviral effectors. Nature 547, 114–117 (2017).
OpenUrl
1. Y. Wang,
2. W. Gao,
3. X. Shi,
4. J. Ding,
5. W. Liu,
6. H. He,
7. K. Wang,
8. F. Shao
, Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin. Nature 547, 99–103 (2017).
OpenUrl
1. A. Zabala-Letona,
2. A. Arruabarrena-Aristorena,
3. N. Martín-Martín,
4. S. Fernandez-Ruiz,
5. J. D. Sutherland,
6. M. Clasquin,
7. J. Tomas-Cortazar,
8. J. Jimenez,
9. I. Torres,
10. P. Quang,
11. P. Ximenez-Embun,
12. R. Bago,
13. A. Ugalde-Olano,
14. A. Loizaga-Iriarte,
15. I. Lacasa-Viscasillas,
16. M. Unda,
17. V. Torrano,
18. D. Cabrera,
19. S. M. van Liempd,
20. Y. Cendon,
21. E. Castro,
22. S. Murray,
23. A. Revandkar,
24. A. Alimonti,
25. Y. Zhang,
26. A. Barnett,
27. G. Lein,
28. D. Pirman,
29. A. R. Cortazar,
30. L. Arreal,
31. L. Prudkin,
32. I. Astobiza,
33. L. Valcarcel-Jimenez,
34. P. Zuñiga-García,
35. I. Fernandez-Dominguez,
36. M. Piva,
37. A. Caro-Maldonado,
38. P. Sánchez-Mosquera,
39. M. Castillo-Martín,
40. V. Serra,
41. N. Beraza,
42. A. Gentilella,
43. G. Thomas,
44. M. Azkargorta,
45. F. Elortza,
46. R. Farràs,
47. D. Olmos,
48. A. Efeyan,
49. J. Anguita,
50. J. Muñoz,
51. J. M. Falcón-Pérez,
52. R. Barrio,
53. T. Macarulla,
54. J. M. Mato,
55. M. L. Martinez-Chantar,
56. C. Cordon-Cardo,
57. A. M. Aransay,
58. K. Marks,
59. J. Baselga,
60. J. Tabernero,
61. P. Nuciforo,
62. B. D. Manning,
63. K. Marjon,
64. A. Carracedo
, mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer. Nature 547, 109–113 (2017).
OpenUrl
1. G. G. Gregorio,
2. M. Masureel,
3. D. Hilger,
4. D. S. Terry,
5. M. Juette,
6. H. Zhao,
7. Z. Zhou,
8. J. M. Perez-Aguilar,
9. M. Hauge,
10. S. Mathiasen,
11. J. A. Javitch,
12. H. Weinstein,
13. B. K. Kobilka,
14. S. C. Blanchard
, Single-molecule analysis of ligand efficacy in β₂AR–G-protein activation. Nature 547, 68–73 (2017).
OpenUrl
1. P. Jin,
2. D. Bulkley,
3. Y. Guo,
4. W. Zhang,
5. Z. Guo,
6. W. Huynh,
7. S. Wu,
8. S. Meltzer,
9. T. Cheng,
10. L. Y. Jan,
11. Y.-N. Jan,
12. Y. Cheng
, Electron cryo-microscopy structure of the mechanotransduction channel NOMPC. Nature 547, 118–122 (2017).
OpenUrl

[1] P. Dash,
A. J. Fiore-Gartland,
T. Hertz,
G. C. Wang,
S. Sharma,
A. Souquette,
J. C. Crawford,
E. B. Clemens,
T. H. O. Nguyen,
K. Kedzierska,
N. L. La Gruta,
P. Bradley,
P. G. Thomas
, Quantifiable predictive features define epitope-specific T cell receptor repertoires. Nature 547, 89–93 (2017).
OpenUrl

[2] P. Dash,

[3] A. J. Fiore-Gartland,

[4] T. Hertz,

[5] G. C. Wang,

[6] S. Sharma,

[7] A. Souquette,

[8] J. C. Crawford,

[9] E. B. Clemens,

[10] T. H. O. Nguyen,

[11] K. Kedzierska,

[12] N. L. La Gruta,

[13] P. Bradley,

[14] P. G. Thomas

[15] J. Glanville,
H. Huang,
A. Nau,
O. Hatton,
L. E. Wagar,
F. Rubelt,
X. Ji,
A. Han,
S. M. Krams,
C. Pettus,
N. Haas,
C. S. Lindestam Arlehamn,
A. Sette,
S. D. Boyd,
T. J. Scriba,
O. M. Martinez,
M. M. Davis
, Identifying specificity groups in the T cell receptor repertoire. Nature 547, 94–98 (2017).
OpenUrl

[16] J. Glanville,

[17] H. Huang,

[18] A. Nau,

[19] O. Hatton,

[20] L. E. Wagar,

[21] F. Rubelt,

[22] X. Ji,

[23] A. Han,

[24] S. M. Krams,

[25] C. Pettus,

[26] N. Haas,

[27] C. S. Lindestam Arlehamn,

[28] A. Sette,

[29] S. D. Boyd,

[30] T. J. Scriba,

[31] O. M. Martinez,

[32] M. M. Davis

[33] S. T. Reddy
, The patterns of T-cell target recognition. Nature 547, 36–38 (2017).
OpenUrl

[34] S. T. Reddy

[35] L. C. Aguado,
S. Schmid,
J. May,
L. R. Sabin,
M. Panis,
D. Blanco-Melo,
J. V. Shim,
D. Sachs,
S. Cherry,
A. E. Simon,
J.-P. Levraud,
B. R. tenOever
, RNase III nucleases from diverse kingdoms serve as antiviral effectors. Nature 547, 114–117 (2017).
OpenUrl

[36] L. C. Aguado,

[37] S. Schmid,

[38] J. May,

[39] L. R. Sabin,

[40] M. Panis,

[41] D. Blanco-Melo,

[42] J. V. Shim,

[43] D. Sachs,

[44] S. Cherry,

[45] A. E. Simon,

[46] J.-P. Levraud,

[47] B. R. tenOever

[48] Y. Wang,
W. Gao,
X. Shi,
J. Ding,
W. Liu,
H. He,
K. Wang,
F. Shao
, Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin. Nature 547, 99–103 (2017).
OpenUrl

[49] Y. Wang,

[50] W. Gao,

[51] X. Shi,

[52] J. Ding,

[53] W. Liu,

[54] H. He,

[55] K. Wang,

[56] F. Shao

[57] A. Zabala-Letona,
A. Arruabarrena-Aristorena,
N. Martín-Martín,
S. Fernandez-Ruiz,
J. D. Sutherland,
M. Clasquin,
J. Tomas-Cortazar,
J. Jimenez,
I. Torres,
P. Quang,
P. Ximenez-Embun,
R. Bago,
A. Ugalde-Olano,
A. Loizaga-Iriarte,
I. Lacasa-Viscasillas,
M. Unda,
V. Torrano,
D. Cabrera,
S. M. van Liempd,
Y. Cendon,
E. Castro,
S. Murray,
A. Revandkar,
A. Alimonti,
Y. Zhang,
A. Barnett,
G. Lein,
D. Pirman,
A. R. Cortazar,
L. Arreal,
L. Prudkin,
I. Astobiza,
L. Valcarcel-Jimenez,
P. Zuñiga-García,
I. Fernandez-Dominguez,
M. Piva,
A. Caro-Maldonado,
P. Sánchez-Mosquera,
M. Castillo-Martín,
V. Serra,
N. Beraza,
A. Gentilella,
G. Thomas,
M. Azkargorta,
F. Elortza,
R. Farràs,
D. Olmos,
A. Efeyan,
J. Anguita,
J. Muñoz,
J. M. Falcón-Pérez,
R. Barrio,
T. Macarulla,
J. M. Mato,
M. L. Martinez-Chantar,
C. Cordon-Cardo,
A. M. Aransay,
K. Marks,
J. Baselga,
J. Tabernero,
P. Nuciforo,
B. D. Manning,
K. Marjon,
A. Carracedo
, mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer. Nature 547, 109–113 (2017).
OpenUrl

[58] A. Zabala-Letona,

[59] A. Arruabarrena-Aristorena,

[60] N. Martín-Martín,

[61] S. Fernandez-Ruiz,

[62] J. D. Sutherland,

[63] M. Clasquin,

[64] J. Tomas-Cortazar,

[65] J. Jimenez,

[66] I. Torres,

[67] P. Quang,

[68] P. Ximenez-Embun,

[69] R. Bago,

[70] A. Ugalde-Olano,

[71] A. Loizaga-Iriarte,

[72] I. Lacasa-Viscasillas,

[73] M. Unda,

[74] V. Torrano,

[75] D. Cabrera,

[76] S. M. van Liempd,

[77] Y. Cendon,

[78] E. Castro,

[79] S. Murray,

[80] A. Revandkar,

[81] A. Alimonti,

[82] Y. Zhang,

[83] A. Barnett,

[84] G. Lein,

[85] D. Pirman,

[86] A. R. Cortazar,

[87] L. Arreal,

[88] L. Prudkin,

[89] I. Astobiza,

[90] L. Valcarcel-Jimenez,

[91] P. Zuñiga-García,

[92] I. Fernandez-Dominguez,

[93] M. Piva,

[94] A. Caro-Maldonado,

[95] P. Sánchez-Mosquera,

[96] M. Castillo-Martín,

[97] V. Serra,

[98] N. Beraza,

[99] A. Gentilella,

[100] G. Thomas,

[101] M. Azkargorta,

[102] F. Elortza,

[103] R. Farràs,

[104] D. Olmos,

[105] A. Efeyan,

[106] J. Anguita,

[107] J. Muñoz,

[108] J. M. Falcón-Pérez,

[109] R. Barrio,

[110] T. Macarulla,

[111] J. M. Mato,

[112] M. L. Martinez-Chantar,

[113] C. Cordon-Cardo,

[114] A. M. Aransay,

[115] K. Marks,

[116] J. Baselga,

[117] J. Tabernero,

[118] P. Nuciforo,

[119] B. D. Manning,

[120] K. Marjon,

[121] A. Carracedo

[122] G. G. Gregorio,
M. Masureel,
D. Hilger,
D. S. Terry,
M. Juette,
H. Zhao,
Z. Zhou,
J. M. Perez-Aguilar,
M. Hauge,
S. Mathiasen,
J. A. Javitch,
H. Weinstein,
B. K. Kobilka,
S. C. Blanchard
, Single-molecule analysis of ligand efficacy in β₂AR–G-protein activation. Nature 547, 68–73 (2017).
OpenUrl

[123] G. G. Gregorio,

[124] M. Masureel,

[125] D. Hilger,

[126] D. S. Terry,

[127] M. Juette,

[128] H. Zhao,

[129] Z. Zhou,

[130] J. M. Perez-Aguilar,

[131] M. Hauge,

[132] S. Mathiasen,

[133] J. A. Javitch,

[134] H. Weinstein,

[135] B. K. Kobilka,

[136] S. C. Blanchard

[137] P. Jin,
D. Bulkley,
Y. Guo,
W. Zhang,
Z. Guo,
W. Huynh,
S. Wu,
S. Meltzer,
T. Cheng,
L. Y. Jan,
Y.-N. Jan,
Y. Cheng
, Electron cryo-microscopy structure of the mechanotransduction channel NOMPC. Nature 547, 118–122 (2017).
OpenUrl

[138] P. Jin,

[139] D. Bulkley,

[140] Y. Guo,

[141] W. Zhang,

[142] Z. Guo,

[143] W. Huynh,

[144] S. Wu,

[145] S. Meltzer,

[146] T. Cheng,

[147] L. Y. Jan,

[148] Y.-N. Jan,

[149] Y. Cheng

Papers of note in Nature 547 (7661)

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