Editors' ChoiceCANCER METASTASIS

Paper of note in Science Translational Medicine 9 (397)

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Science Signaling  11 Jul 2017:
Vol. 10, Issue 487, eaao3021
DOI: 10.1126/scisignal.aao3021

This week’s article describes how chemotherapy unintentionally enhances the dissemination of cancer cells into the circulation.

CANCER

Closing the door to cancer cells

Karagiannis et al. report that chemotherapy promotes metastatic dissemination of cancer cells, despite decreasing the size of the tumor itself. Inhibiting the angiopoietin receptor TIE2 might prevent chemotherapy-induced metastasis.

Highlighted Article

    1. G. S. Karagiannis,
    2. J. M. Pastoriza,
    3. Y. Wang,
    4. A. S. Harney,
    5. D. Entenberg,
    6. J. Pignatelli,
    7. V. P. Sharma,
    8. E. A. Xue,
    9. E. Cheng,
    10. T. M. D’Alfonso,
    11. J. G. Jones,
    12. J. Anampa,
    13. T. E. Rohan,
    14. J. A. Sparano,
    15. J. S. Condeelis,
    16. M. H. Oktay
    , Neoadjuvant chemotherapy induces breast cancer metastasis through a TMEM-mediated mechanism. Sci. Transl. Med. 9, eaan0026 (2017).
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  • Paper of note in Science Translational Medicine 9 (397)

    By Leslie K. Ferrarelli

    Science Signaling

    This week’s article describes how chemotherapy unintentionally enhances the dissemination of cancer cells into the circulation.

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