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Research ArticleNeurodegeneration
Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson’s disease
- View ORCID ProfileZhong-Can Chen1,
- View ORCID ProfileWei Zhang1,
- Ling-Ling Chua2,
- View ORCID ProfileChou Chai3,
- Rong Li4,
- Lin Lin5,6,
- Zhen Cao1,
- Dario C. Angeles2,*,
- Lawrence W. Stanton5,
- Jian-He Peng4,†,
- View ORCID ProfileZhi-Dong Zhou2,7,
- View ORCID ProfileKah-Leong Lim3,7,8,
- View ORCID ProfileLi Zeng1,7,‡, and
- View ORCID ProfileEng-King Tan2,7,9,‡
- 1Neural Stem Cell Research Laboratory, Research Department, National Neuroscience Institute, Singapore 308433, Singapore.
- 2Research Department, National Neuroscience Institute, Singapore General Hospital (SGH) Campus, Singapore 169856, Singapore.
- 3Neurodegeneration Laboratory, Research Department, National Neuroscience Institute, Singapore 308433, Singapore.
- 4Analytical Mass Spectrometry Laboratory, Experimental Therapeutics Centre, Agency of Science, Technology and Research (A*STAR), Singapore 138669, Singapore.
- 5Stem Cell and Developmental Biology Group, Genome Institute of Singapore, A*STAR, Singapore 138672, Singapore.
- 6National University of Singapore (NUS) Graduate School for Integrative Sciences and Engineering, NUS, Singapore 117456, Singapore.
- 7Neuroscience and Behavioral Disorders Program, DUKE-NUS Graduate Medical School, Singapore 169857, Singapore.
- 8Department of Physiology, Yong Loo Lin School of Medicine, NUS, Singapore 117597, Singapore.
- 9Department of Neurology, National Neuroscience Institute, SGH Campus, Singapore 169856, Singapore.
- ↵‡Corresponding author. Email: li_zeng{at}nni.com.sg (L.Z.); tan.eng.king{at}sgh.com.sg (E.-K.T.)
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Science Signaling 18 Jul 2017:
Vol. 10, Issue 488, eaam6790
DOI: 10.1126/scisignal.aam6790
Vol. 10, Issue 488, eaam6790
DOI: 10.1126/scisignal.aam6790
Zhong-Can Chen
1Neural Stem Cell Research Laboratory, Research Department, National Neuroscience Institute, Singapore 308433, Singapore.
Wei Zhang
1Neural Stem Cell Research Laboratory, Research Department, National Neuroscience Institute, Singapore 308433, Singapore.
Ling-Ling Chua
2Research Department, National Neuroscience Institute, Singapore General Hospital (SGH) Campus, Singapore 169856, Singapore.
Chou Chai
3Neurodegeneration Laboratory, Research Department, National Neuroscience Institute, Singapore 308433, Singapore.
Rong Li
4Analytical Mass Spectrometry Laboratory, Experimental Therapeutics Centre, Agency of Science, Technology and Research (A*STAR), Singapore 138669, Singapore.
Lin Lin
5Stem Cell and Developmental Biology Group, Genome Institute of Singapore, A*STAR, Singapore 138672, Singapore.
6National University of Singapore (NUS) Graduate School for Integrative Sciences and Engineering, NUS, Singapore 117456, Singapore.
Zhen Cao
1Neural Stem Cell Research Laboratory, Research Department, National Neuroscience Institute, Singapore 308433, Singapore.
Dario C. Angeles
2Research Department, National Neuroscience Institute, Singapore General Hospital (SGH) Campus, Singapore 169856, Singapore.
Lawrence W. Stanton
5Stem Cell and Developmental Biology Group, Genome Institute of Singapore, A*STAR, Singapore 138672, Singapore.
Jian-He Peng
4Analytical Mass Spectrometry Laboratory, Experimental Therapeutics Centre, Agency of Science, Technology and Research (A*STAR), Singapore 138669, Singapore.
Zhi-Dong Zhou
2Research Department, National Neuroscience Institute, Singapore General Hospital (SGH) Campus, Singapore 169856, Singapore.
7Neuroscience and Behavioral Disorders Program, DUKE-NUS Graduate Medical School, Singapore 169857, Singapore.
Kah-Leong Lim
3Neurodegeneration Laboratory, Research Department, National Neuroscience Institute, Singapore 308433, Singapore.
7Neuroscience and Behavioral Disorders Program, DUKE-NUS Graduate Medical School, Singapore 169857, Singapore.
8Department of Physiology, Yong Loo Lin School of Medicine, NUS, Singapore 117597, Singapore.
Li Zeng
1Neural Stem Cell Research Laboratory, Research Department, National Neuroscience Institute, Singapore 308433, Singapore.
7Neuroscience and Behavioral Disorders Program, DUKE-NUS Graduate Medical School, Singapore 169857, Singapore.
Eng-King Tan
2Research Department, National Neuroscience Institute, Singapore General Hospital (SGH) Campus, Singapore 169856, Singapore.
7Neuroscience and Behavioral Disorders Program, DUKE-NUS Graduate Medical School, Singapore 169857, Singapore.
9Department of Neurology, National Neuroscience Institute, SGH Campus, Singapore 169856, Singapore.
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