Contents
25 July 2017
Vol 10, Issue 489
Vol 10, Issue 489
Research Articles
- Enhancing natriuretic peptide signaling in adipose tissue, but not in muscle, protects against diet-induced obesity and insulin resistance
Natriuretic peptide receptor C deficiency improves metabolism through signaling in adipose tissue, rather than in skeletal muscle.
- The glucocorticoid-Angptl4-ceramide axis induces insulin resistance through PP2A and PKCζ
Insulin resistance associated with glucocorticoid treatment may be alleviated by inhibiting the synthesis of ceramides or their effectors.
Podcast
- Science Signaling Podcast for 25 July 2017: Natriuretic peptide signaling in metabolism
Natriuretic peptides protect mice from the metabolic consequences of a high-fat diet by acting on adipose tissue, not skeletal muscle (Wu et al. in 25 July 2017 issue).
Editors' Choice
- Olfactory control of metabolism
Activation of olfactory sensory neurons promotes adiposity and insulin resistance in mice.
- Paper of note in Science 357 (6348)
This week’s article is a review that highlights how epigenetic factors may make cells more or less susceptible to oncogenic transformation.
- Papers of note in Science Translational Medicine 9 (399)
This week’s articles describe how CAR T cells might be used to treat recurrent glioblastoma and how microvascular cells induce inflammation in the autoimmune disease giant cell arteritis.
- Papers of note in Nature 547 (7663)
This week’s articles identify a surprising role for dopamine outside the nervous system and a cryptic binding pocket that promotes leak currents through a potassium channel.
About The Cover
Online Cover This week features a Research Article that shows that natriuretic peptides improve metabolism by signaling in adipose tissue, not in skeletal muscle. The image shows hematoxylin and eosin staining of gonadal white adipose tissue from a control mouse on a high-fat diet. [Image: Wei Wu/Sanford Burnham Prebys Medical Discovery Institute, Orlando, USA, and Fudan University, Shanghai, China]