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Papers of note in Science Translational Medicine 9 (399)

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Science Signaling  25 Jul 2017:
Vol. 10, Issue 489, eaao4313
DOI: 10.1126/scisignal.aao4313

This week’s articles describe how CAR T cells might be used to treat recurrent glioblastoma and how microvascular cells induce inflammation in the autoimmune disease giant cell arteritis.


CAR T cell therapy for glioblastoma

O’Rourke et al. show in a patient trial that intravenous delivery of EGFRvIII-targeted CAR T cells may be able to target recurrent glioblastoma but induces an immunosuppressive microenvironment that could hamper treatment efficacy.


Notching up inflammation

Wen et al. report that increased secretion of VEGF stimulates Jagged1-Notch signaling between microvascular endothelial cells and proinflammatory T effector cells, causing vascular inflammation in the autoimmune disease giant cell arteritis.

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