Papers of note in Science Translational Medicine 9 (399)

Leslie K. Ferrarelli

doi:10.1126/scisignal.aao4313

This week’s articles describe how CAR T cells might be used to treat recurrent glioblastoma and how microvascular cells induce inflammation in the autoimmune disease giant cell arteritis.

CANCER IMMUNOTHERAPY

CAR T cell therapy for glioblastoma

O’Rourke et al. show in a patient trial that intravenous delivery of EGFRvIII-targeted CAR T cells may be able to target recurrent glioblastoma but induces an immunosuppressive microenvironment that could hamper treatment efficacy.

INFLAMMATION

Notching up inflammation

Wen et al. report that increased secretion of VEGF stimulates Jagged1-Notch signaling between microvascular endothelial cells and proinflammatory T effector cells, causing vascular inflammation in the autoimmune disease giant cell arteritis.

Highlighted Articles

1. D. M. O’Rourke,
2. M. P. Nasrallah,
3. A. Desai,
4. J. J. Melenhorst,
5. K. Mansfield,
6. J. J. D. Morrissette,
7. M. Martinez-Lage,
8. S. Brem,
9. E. Maloney,
10. A. Shen,
11. R. Isaacs,
12. S. Mohan,
13. G. Plesa,
14. S. F. Lacey,
15. J.-M. Navenot,
16. Z. Zheng,
17. B. L. Levine,
18. H. Okada,
19. C. H. June,
20. J. L. Brogdon,
21. M. V. Maus
, A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma. Sci. Transl. Med. 9, eaaa0984 (2017).
OpenUrl Abstract/FREE Full Text
1. Z. Wen,
2. Y. Shen,
3. G. Berry,
4. F. Shahram,
5. Y. Li,
6. R. Watanabe,
7. Y. J. Liao,
8. J. J. Goronzy,
9. C. M. Weyand
, The microvascular niche instructs T cells in large vessel vasculitis via the VEGF-Jagged1-Notch pathway. Sci. Transl. Med. 9, eaal3322 (2017).
OpenUrl Abstract/FREE Full Text

View Abstract

This week’s articles describe how CAR T cells might be used to treat recurrent glioblastoma and how microvascular cells induce inflammation in the autoimmune disease giant cell arteritis.

[1] D. M. O’Rourke,
M. P. Nasrallah,
A. Desai,
J. J. Melenhorst,
K. Mansfield,
J. J. D. Morrissette,
M. Martinez-Lage,
S. Brem,
E. Maloney,
A. Shen,
R. Isaacs,
S. Mohan,
G. Plesa,
S. F. Lacey,
J.-M. Navenot,
Z. Zheng,
B. L. Levine,
H. Okada,
C. H. June,
J. L. Brogdon,
M. V. Maus
, A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma. Sci. Transl. Med. 9, eaaa0984 (2017).
OpenUrl Abstract/FREE Full Text

[2] D. M. O’Rourke,

[3] M. P. Nasrallah,

[4] A. Desai,

[5] J. J. Melenhorst,

[6] K. Mansfield,

[7] J. J. D. Morrissette,

[8] M. Martinez-Lage,

[9] S. Brem,

[10] E. Maloney,

[11] A. Shen,

[12] R. Isaacs,

[13] S. Mohan,

[14] G. Plesa,

[15] S. F. Lacey,

[16] J.-M. Navenot,

[17] Z. Zheng,

[18] B. L. Levine,

[19] H. Okada,

[20] C. H. June,

[21] J. L. Brogdon,

[22] M. V. Maus

[23] Z. Wen,
Y. Shen,
G. Berry,
F. Shahram,
Y. Li,
R. Watanabe,
Y. J. Liao,
J. J. Goronzy,
C. M. Weyand
, The microvascular niche instructs T cells in large vessel vasculitis via the VEGF-Jagged1-Notch pathway. Sci. Transl. Med. 9, eaal3322 (2017).
OpenUrl Abstract/FREE Full Text

[24] Z. Wen,

[25] Y. Shen,

[26] G. Berry,

[27] F. Shahram,

[28] Y. Li,

[29] R. Watanabe,

[30] Y. J. Liao,

[31] J. J. Goronzy,

[32] C. M. Weyand

Papers of note in Science Translational Medicine 9 (399)

Highlighted Articles

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