Contents
01 August 2017
Vol 10, Issue 490
Vol 10, Issue 490
Research Article
- High glucose–induced ROS activates TRPM2 to trigger lysosomal membrane permeabilization and Zn2+-mediated mitochondrial fission
ROS produced in response to high glucose trigger mitochondrial fragmentation through a TRPM2-mediated pathway.
Research Resource
- A cluster of immunoresolvents links coagulation to innate host defense in human blood
Factors generated by blood coagulation that elicit immune responses that protect the host are identified.
Editors' Choice
- Messaging with naked RNA
Activated stromal cells release an unshielded RNA in exosomes that induces interferon-stimulated gene expression in breast cancer cells and tumor growth.
- Gut microbes help turn up the heat?
Cold temperatures induce a switch in cholesterol metabolism that alters the gut microbiota and facilitates thermogenesis.
- Papers of note in Science Immunology 2 (13)
This month’s articles show how agonists of the STING-cGAS pathway in dendritic cells might serve as vaccine adjuvants and how tumor-derived exosomes increase the abundance of an immunosuppressive molecule on monocytes.
- Papers of note in Science Translational Medicine 9 (400)
This week’s articles describe new strategies to selectively target therapeutics to tumors.
- Papers of note in Science 357 (6349)
This week’s articles identify a mechanism that targets incompletely translated polypeptides for degradation and review the various roles of a class of dietary tryptophan metabolites in health and disease.
- Papers of note in Nature 547 (7664)
This week’s articles highlight mechanisms that sensitize cancer cells to therapy; a protease involved in radiation-induced bystander effects; the structural basis of cannabinoid receptor activation; and the detection of water currents by fish.
About The Cover
Online Cover This week features a Research Article that describes how ROS produced in response to high glucose trigger mitochondrial fragmentation through a TRPM2-mediated pathway. The image shows fragmented mitochondria in endothelial cells exposed to high glucose. [Image: Asipu Sivaprasadarao and Alistair Curd/University of Leeds, UK]