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Papers of note in Science Translational Medicine 9 (400)

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Science Signaling  01 Aug 2017:
Vol. 10, Issue 490, eaao4937
DOI: 10.1126/scisignal.aao4937

This week’s articles describe new strategies to selectively target therapeutics to tumors.

CANCER THERAPY

A stiff punishment for tumors

Liu et al. engineered mechanoresponsive mesenchymal stem cells to act as vehicles for tumor-targeted drug delivery.

BET-ting on a new drug combination

Yang et al. discovered that inhibiting the epigenetic regulator BET causes a DNA repair deficiency that sensitizes tumors to PARP inhibitors.

Highlighted Articles

    1. L. Liu,
    2. S. X. Zhang,
    3. W. Liao,
    4. H. P. Farhoodi,
    5. C. W. Wong,
    6. C. C. Chen,
    7. A. I. Ségaliny,
    8. J. V. Chacko,
    9. L. P. Nguyen,
    10. M. Lu,
    11. G. Polovin,
    12. E. J. Pone,
    13. T. L. Downing,
    14. D. A. Lawson,
    15. M. A. Digman,
    16. W. Zhao
    , Mechanoresponsive stem cells to target cancer metastases through biophysical cues. Sci. Transl. Med. 9, eaan2966 (2017).
    OpenUrlAbstract/FREE Full Text
    1. L. Yang,
    2. Y. Zhang,
    3. W. Shan,
    4. Z. Hu,
    5. J. Yuan,
    6. J. Pi,
    7. Y. Wang,
    8. L. Fan,
    9. Z. Tang,
    10. C. Li,
    11. X. Hu,
    12. J. L. Tanyi,
    13. Y. Fan,
    14. Q. Huang,
    15. K. Montone,
    16. C. V. Dang,
    17. L. Zhang
    , Repression of BET activity sensitizes homologous recombination-proficient cancers to PARP inhibition. Sci. Transl. Med. 9, eaal1645 (2017).
    OpenUrlAbstract/FREE Full Text

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  • Papers of note in Science Translational Medicine 9 (400)

    By Leslie K. Ferrarelli

    Science Signaling

    This week’s articles describe new strategies to selectively target therapeutics to tumors.

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