Editors' ChoiceCellular and Molecular Signaling

Papers of note in Science 357 (6349)

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Science Signaling  01 Aug 2017:
Vol. 10, Issue 490, eaao5008
DOI: 10.1126/scisignal.aao5008

This week’s articles identify a mechanism that targets incompletely translated polypeptides for degradation and review the various roles of a class of dietary tryptophan metabolites in health and disease.


A tale of CAT tails

Kostova et al. report that elongation of stalled peptides during protein translation promotes degradation by the ribosome quality control complex.


From stomach ache to depression

In a review, Cervenka et al. explain that tryptophan metabolites integrate the cross-talk between metabolic, microbial, immune, and neural systems.

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