This week’s articles identify a mechanism that targets incompletely translated polypeptides for degradation and review the various roles of a class of dietary tryptophan metabolites in health and disease.
PROTEOSTASIS
A tale of CAT tails
Kostova et al. report that elongation of stalled peptides during protein translation promotes degradation by the ribosome quality control complex.
METABOLISM
From stomach ache to depression
In a review, Cervenka et al. explain that tryptophan metabolites integrate the cross-talk between metabolic, microbial, immune, and neural systems.
