Research ArticleMetabolism TRIF-dependent Toll-like receptor signaling suppresses Scd1 transcription in hepatocytes and prevents diet-induced hepatic steatosis View ORCID ProfileJing Chen1,2,*, View ORCID ProfileJin Li1,3,4,*, View ORCID ProfileJensen H. C. Yiu1,2, View ORCID ProfileJenny K. W. Lam2, View ORCID ProfileChi-Ming Wong1,3, Bernhard Dorweiler5, View ORCID ProfileAimin Xu1,2,3,†, and View ORCID ProfileConnie W. Woo1,2,†1State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong 999077, China.2Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong 999077, China.3Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong 999077, China.4Department of Endocrinology, Second Hospital of Shanxi Medical University, Taiyuan 030001, China.5Division of Vascular Surgery, Department of Cardiothoracic and Vascular Surgery, University Medical Center Mainz, Mainz 55131, Germany.↵†Corresponding author. Email: cwhwoo{at}hku.hk (C.W.W.); amxu{at}hku.hk (A.X.)↵* These authors contributed equally to this work. See allHide authors and affiliations Science Signaling 08 Aug 2017:Vol. 10, Issue 491, eaal3336DOI: 10.1126/scisignal.aal3336 Jing Chen 1State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong 999077, China.2Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong 999077, China.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Jing Chen Jin Li 1State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong 999077, China.3Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong 999077, China.4Department of Endocrinology, Second Hospital of Shanxi Medical University, Taiyuan 030001, China.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Jin Li Jensen H. C. Yiu 1State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong 999077, China.2Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong 999077, China.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Jensen H. C. Yiu Jenny K. W. Lam 2Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong 999077, China.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Jenny K. W. Lam Chi-Ming Wong 1State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong 999077, China.3Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong 999077, China.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Chi-Ming Wong Bernhard Dorweiler 5Division of Vascular Surgery, Department of Cardiothoracic and Vascular Surgery, University Medical Center Mainz, Mainz 55131, Germany.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Aimin Xu 1State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong 999077, China.2Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong 999077, China.3Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong 999077, China.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Aimin Xu For correspondence: cwhwoo@hku.hk amxu@hku.hk Connie W. Woo 1State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong 999077, China.2Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong 999077, China.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Connie W. Woo For correspondence: cwhwoo@hku.hk amxu@hku.hk Article Figures & Data Info & Metrics eLetters PDF Article Information vol. 10 no. 491 DOI: https://doi.org/10.1126/scisignal.aal3336 PubMed: 28790196 Published By: Science Signaling Print ISSN: 1945-0877 Online ISSN: 1937-9145 History: Received November 4, 2016Resubmitted April 13, 2017Accepted July 21, 2017 . Copyright & Usage: Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works http://www.sciencemag.org/about/science-licenses-journal-article-reuseThis is an article distributed under the terms of the Science Journals Default License. Author Information Altmetric Article usage Article lifetimeLast 6 monthsThis monthArticle usage: August 2017 to February 2021 AbstractFullPdf Aug 20173978128226 Sep 20171954739 Oct 20171332134 Nov 2017862616 Dec 2017871210 Jan 2018851721 Feb 20188196 Mar 20181552423 Apr 2018125228 May 2018891212 Jun 201882116 Jul 201885124 Aug 2018165630 Sep 201806632 Oct 201808327 Nov 2018012522 Dec 2018011624 Jan 2019313129 Feb 201926633 Mar 201928456 Apr 201906273 May 201925059 Jun 201903230 Jul 201925243 Aug 201955023 Sep 201965721 Oct 201934922 Nov 201935420 Dec 201975419 Jan 202026716 Feb 202052717 Mar 202003318 Apr 202013214 May 202023914 Jun 202093424 Jul 20200225 Aug 202023514 Sep 202092019 Oct 202003713 Nov 202014622 Dec 202023318 Jan 202134858 Feb 202111720 View Full Text
TRIF-dependent Toll-like receptor signaling suppresses Scd1 transcription in hepatocytes and prevents diet-induced hepatic steatosis By Jing Chen, Jin Li, Jensen H. C. Yiu, Jenny K. W. Lam, Chi-Ming Wong, Bernhard Dorweiler, Aimin Xu, Connie W. Woo Science Signaling08 Aug 2017 A TRIF-dependent pathway that restricts viral infection also prevents diet-induced hepatic steatosis. Supplementary Materials
TRIF-dependent Toll-like receptor signaling suppresses Scd1 transcription in hepatocytes and prevents diet-induced hepatic steatosis By Jing Chen, Jin Li, Jensen H. C. Yiu, Jenny K. W. Lam, Chi-Ming Wong, Bernhard Dorweiler, Aimin Xu, Connie W. Woo Science Signaling08 Aug 2017 A TRIF-dependent pathway that restricts viral infection also prevents diet-induced hepatic steatosis. Supplementary Materials