Research ArticleMetabolism
TRIF-dependent Toll-like receptor signaling suppresses Scd1 transcription in hepatocytes and prevents diet-induced hepatic steatosis
- View ORCID ProfileJing Chen1,2,*,
- View ORCID ProfileJin Li1,3,4,*,
- View ORCID ProfileJensen H. C. Yiu1,2,
- View ORCID ProfileJenny K. W. Lam2,
- View ORCID ProfileChi-Ming Wong1,3,
- Bernhard Dorweiler5,
- View ORCID ProfileAimin Xu1,2,3,†, and
- View ORCID ProfileConnie W. Woo1,2,†
- 1State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong 999077, China.
- 2Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong 999077, China.
- 3Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong 999077, China.
- 4Department of Endocrinology, Second Hospital of Shanxi Medical University, Taiyuan 030001, China.
- 5Division of Vascular Surgery, Department of Cardiothoracic and Vascular Surgery, University Medical Center Mainz, Mainz 55131, Germany.
- ↵†Corresponding author. Email: cwhwoo{at}hku.hk (C.W.W.); amxu{at}hku.hk (A.X.)
↵* These authors contributed equally to this work.
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Science Signaling 08 Aug 2017:
Vol. 10, Issue 491, eaal3336
DOI: 10.1126/scisignal.aal3336
Vol. 10, Issue 491, eaal3336
DOI: 10.1126/scisignal.aal3336
Jing Chen
1State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong 999077, China.
2Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong 999077, China.
Jin Li
1State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong 999077, China.
3Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong 999077, China.
4Department of Endocrinology, Second Hospital of Shanxi Medical University, Taiyuan 030001, China.
Jensen H. C. Yiu
1State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong 999077, China.
2Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong 999077, China.
Jenny K. W. Lam
2Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong 999077, China.
Chi-Ming Wong
1State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong 999077, China.
3Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong 999077, China.
Bernhard Dorweiler
5Division of Vascular Surgery, Department of Cardiothoracic and Vascular Surgery, University Medical Center Mainz, Mainz 55131, Germany.
Aimin Xu
1State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong 999077, China.
2Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong 999077, China.
3Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong 999077, China.
Connie W. Woo
1State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong 999077, China.
2Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong 999077, China.
