Papers of note in Science Translational Medicine 9 (401)

Leslie K. Ferrarelli

doi:10.1126/scisignal.aao4938

This week’s articles describe a way to enhance BH3 mimetics in cancer therapy and a method to achieve targeted delivery of miRNAs to tumors.

CANCER THERAPY

Cutting off another tumor lifeline

Merino et al. report that inhibiting the prosurvival protein MCL-1 enhances the effectiveness of conventional BH3 mimetic therapies in triple-negative and HER2-amplified breast cancer.

Fixing with folate

Orellana et al . developed a nontoxic way to deliver microRNAs directly to tumors in vivo using folate.

Highlighted Articles

1. D. Merino,
2. J. R. Whittle,
3. F. Vaillant,
4. A. Serrano,
5. J.-N. Gong,
6. G. Giner,
7. A. L. Maragno,
8. M. Chanrion,
9. E. Schneider,
10. B. Pal,
11. X. Li,
12. G. Dewson,
13. J. Gräsel,
14. K. Liu,
15. N. Lalaoui,
16. D. Segal,
17. M. J. Herold,
18. D. C. S. Huang,
19. G. K. Smyth,
20. O. Geneste,
21. G. Lessene,
22. J. E. Visvader,
23. G. J. Lindeman
, Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer. Sci. Transl. Med. 9, eaam7049 (2017).
OpenUrl Abstract/FREE Full Text
1. E. A. Orellana,
2. S. Tenneti,
3. L. Rangasamy,
4. L. T. Lyle,
5. P. S. Low,
6. A. L. Kasinski
, FolamiRs: Ligand-targeted, vehicle-free delivery of microRNAs for the treatment of cancer. Sci. Transl. Med. 9, eaam9327 (2017).
OpenUrl Abstract/FREE Full Text

View Abstract

[1] D. Merino,
J. R. Whittle,
F. Vaillant,
A. Serrano,
J.-N. Gong,
G. Giner,
A. L. Maragno,
M. Chanrion,
E. Schneider,
B. Pal,
X. Li,
G. Dewson,
J. Gräsel,
K. Liu,
N. Lalaoui,
D. Segal,
M. J. Herold,
D. C. S. Huang,
G. K. Smyth,
O. Geneste,
G. Lessene,
J. E. Visvader,
G. J. Lindeman
, Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer. Sci. Transl. Med. 9, eaam7049 (2017).
OpenUrl Abstract/FREE Full Text

[2] D. Merino,

[3] J. R. Whittle,

[4] F. Vaillant,

[5] A. Serrano,

[6] J.-N. Gong,

[7] G. Giner,

[8] A. L. Maragno,

[9] M. Chanrion,

[10] E. Schneider,

[11] B. Pal,

[12] X. Li,

[13] G. Dewson,

[14] J. Gräsel,

[15] K. Liu,

[16] N. Lalaoui,

[17] D. Segal,

[18] M. J. Herold,

[19] D. C. S. Huang,

[20] G. K. Smyth,

[21] O. Geneste,

[22] G. Lessene,

[23] J. E. Visvader,

[24] G. J. Lindeman

[25] E. A. Orellana,
S. Tenneti,
L. Rangasamy,
L. T. Lyle,
P. S. Low,
A. L. Kasinski
, FolamiRs: Ligand-targeted, vehicle-free delivery of microRNAs for the treatment of cancer. Sci. Transl. Med. 9, eaam9327 (2017).
OpenUrl Abstract/FREE Full Text

[26] E. A. Orellana,

[27] S. Tenneti,

[28] L. Rangasamy,

[29] L. T. Lyle,

[30] P. S. Low,

[31] A. L. Kasinski

Papers of note in Science Translational Medicine 9 (401)

Highlighted Articles

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