Papers of note in Nature 547 (7665)

Leslie K. Ferrarelli

doi:10.1126/scisignal.aao5734

This week’s articles highlight the role of a sugar metabolite in cellular energy sensing, how the hypothalamus controls aging, and how structural changes in protein complexes regulate the development and maintenance of plant roots.

METABOLISM

Sugar regulation of AMPK

Zhang et al. found that fructose-1,6-bisphosphate, which is produced during glucose metabolism, inhibits activation of the kinase AMPK (see also Kemp and Oakhill).

AGING

Vitality in hypothalamic miRNAs

Y. Zhang et al. report that the decline of exosomal release of microRNAs from stem cells in the hypothalamus contributes to aging.

PLANT BIOLOGY

Root specification through complex conformation

Long et al. found that in Arabidopsis roots, protein complexes change their conformation in a cell type–dependent manner to regulate gene expression.

Highlighted Articles

1. C.-S. Zhang,
2. S. A. Hawley,
3. Y. Zong,
4. M. Li,
5. Z. Wang,
6. A. Gray,
7. T. Ma,
8. J. Cui,
9. J.-W. Feng,
10. M. Zhu,
11. Y.-Q. Wu,
12. T. Y. Li,
13. Z. Ye,
14. S.-Y. Lin,
15. H. Yin,
16. H.-L. Piao,
17. D. G. Hardie,
18. S.-C. Lin
, Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK. Nature 548, 112–116 (2017).
OpenUrl
1. B. E. Kemp,
2. J. S. Oakhill
, Metabolism: Energy sensing through a sugar diphosphate. Nature 548, 36–37 (2017).
OpenUrl
1. Y. Zhang,
2. M. S. Kim,
3. B. Jia,
4. J. Yan,
5. J. P. Zuniga-Hertz,
6. C. Han,
7. D. Cai
, Hypothalamic stem cells control ageing speed partly through exosomal miRNAs. Nature 548, 52–57 (2017).
OpenUrl
1. Y. Long,
2. Y. Stahl,
3. S. Weidtkamp-Peters,
4. M. Postma,
5. W. Zhou,
6. J. Goedhart,
7. M.-I. Sánchez-Pérez,
8. T. W. J. Gadella,
9. R. Simon,
10. B. Scheres,
11. I. Blilou
, In vivo FRET-FLIM reveals cell-type-specific protein interactions in Arabidopsis roots. Nature 548, 97–102 (2017).
OpenUrl

[1] C.-S. Zhang,
S. A. Hawley,
Y. Zong,
M. Li,
Z. Wang,
A. Gray,
T. Ma,
J. Cui,
J.-W. Feng,
M. Zhu,
Y.-Q. Wu,
T. Y. Li,
Z. Ye,
S.-Y. Lin,
H. Yin,
H.-L. Piao,
D. G. Hardie,
S.-C. Lin
, Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK. Nature 548, 112–116 (2017).
OpenUrl

[2] C.-S. Zhang,

[3] S. A. Hawley,

[4] Y. Zong,

[5] M. Li,

[6] Z. Wang,

[7] A. Gray,

[8] T. Ma,

[9] J. Cui,

[10] J.-W. Feng,

[11] M. Zhu,

[12] Y.-Q. Wu,

[13] T. Y. Li,

[14] Z. Ye,

[15] S.-Y. Lin,

[16] H. Yin,

[17] H.-L. Piao,

[18] D. G. Hardie,

[19] S.-C. Lin

[20] B. E. Kemp,
J. S. Oakhill
, Metabolism: Energy sensing through a sugar diphosphate. Nature 548, 36–37 (2017).
OpenUrl

[21] B. E. Kemp,

[22] J. S. Oakhill

[23] Y. Zhang,
M. S. Kim,
B. Jia,
J. Yan,
J. P. Zuniga-Hertz,
C. Han,
D. Cai
, Hypothalamic stem cells control ageing speed partly through exosomal miRNAs. Nature 548, 52–57 (2017).
OpenUrl

[24] Y. Zhang,

[25] M. S. Kim,

[26] B. Jia,

[27] J. Yan,

[28] J. P. Zuniga-Hertz,

[29] C. Han,

[30] D. Cai

[31] Y. Long,
Y. Stahl,
S. Weidtkamp-Peters,
M. Postma,
W. Zhou,
J. Goedhart,
M.-I. Sánchez-Pérez,
T. W. J. Gadella,
R. Simon,
B. Scheres,
I. Blilou
, In vivo FRET-FLIM reveals cell-type-specific protein interactions in Arabidopsis roots. Nature 548, 97–102 (2017).
OpenUrl

[32] Y. Long,

[33] Y. Stahl,

[34] S. Weidtkamp-Peters,

[35] M. Postma,

[36] W. Zhou,

[37] J. Goedhart,

[38] M.-I. Sánchez-Pérez,

[39] T. W. J. Gadella,

[40] R. Simon,

[41] B. Scheres,

[42] I. Blilou

Papers of note in Nature 547 (7665)

Highlighted Articles

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