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Research ArticleCancer therapy
Loss of SPDEF and gain of TGFBI activity after androgen deprivation therapy promote EMT and bone metastasis of prostate cancer
- View ORCID ProfileWei-Yu Chen1,2,
- Yuan-Chin Tsai3,
- Hsiu-Lien Yeh4,
- View ORCID ProfileFlorent Suau5,
- Kuo-Ching Jiang3,
- Ai-Ning Shao3,
- Jiaoti Huang6, and
- View ORCID ProfileYen-Nien Liu3,*
- 1Department of Pathology, Wan Fang Hospital, Taipei Medical University, Taipei 11031, Taiwan.
- 2Department of Pathology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
- 3Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.
- 4Institute of Information System and Applications, National Tsing Hua University, Hsinchu 30013, Taiwan.
- 5Department of Microbiology, Faculty of Pharmacy, Dicle University, Diyarbakir 21280, Turkey.
- 6Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA.
- ↵*Corresponding author. Email: liuy{at}tmu.edu.tw
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Science Signaling 15 Aug 2017:
Vol. 10, Issue 492, eaam6826
DOI: 10.1126/scisignal.aam6826
Vol. 10, Issue 492, eaam6826
DOI: 10.1126/scisignal.aam6826
Wei-Yu Chen
1Department of Pathology, Wan Fang Hospital, Taipei Medical University, Taipei 11031, Taiwan.
2Department of Pathology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Yuan-Chin Tsai
3Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.
Hsiu-Lien Yeh
4Institute of Information System and Applications, National Tsing Hua University, Hsinchu 30013, Taiwan.
Florent Suau
5Department of Microbiology, Faculty of Pharmacy, Dicle University, Diyarbakir 21280, Turkey.
Kuo-Ching Jiang
3Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.
Ai-Ning Shao
3Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.
Jiaoti Huang
6Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA.
Yen-Nien Liu
3Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.
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